Results 51 to 60 of about 895,919 (342)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
BMC Sports Science, Medicine and RehabilitationAim To identify the effects of strength and balance training on dynamic balance and patient reported outcomes in people with chronic ankle instability(CAI).
Yuying Su, Wei Li, Changbo Pan, Yu Shi
doaj +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
The Impact of Stroboscopic Visual Conditions on the Performance of Elite Curling Athletes
LifeBackground: In elite curling, precise time perception, speed control, and accuracy are critical components of performance. Stroboscopic training enhances visual processing speed, reaction time, motor skill control, and cognitive abilities by challenging ...
Tianhe Li +5 more
doaj +1 more source
Conditional independence, conditional mixing and conditional association [PDF]
Annals of the Institute of Statistical Mathematics, 2007 Some properties of conditionally independent random variables are studied. Conditional versions of generalized Borel-Cantelli lemma, generalized Kolmogorov’s inequality and generalized Hajek-Renyi inequality are proved. As applications, a conditional version of the strong law of large numbers for conditionally independent random variables and a ...
openaire +2 more sources
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Placebos as a Source of Agency: Evidence and Implications
Frontiers in Psychiatry, 2019 Bioethical discussions surrounding the use of placebos in clinical practice have long revolved around the moral permissibility of deceiving a patient if it is likely to benefit them.
Phoebe Friesen
doaj +1 more source
FEBS Letters, EarlyView.In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri +8 more
wiley +1 more source
CHANGES IN PHYSIOLOGICAL PARAMETERS IN CADET WRESTLERS FOLLOWING A 4-WEEK GENERAL PREPARATION PHASE [PDF]
Fizičeskoe Vospitanie Studentov, 2011 The purpose of this study was to investigate the changes in physiological parameters in cadet wrestlers following a 4-week general preparation phase of training.
Bahman Mirzaei +4 more
doaj