Results 61 to 70 of about 514,614 (257)

A 24-week multi-component exercise program improves cognition and body composition in older adults with mild cognitive impairment: a randomized controlled trial

Frontiers in Aging Neuroscience
BackgroundThis study investigated whether a 24-week, community-based multicomponent exercise intervention (MCEI) can improve body composition and cognitive function in older adults with mild cognitive impairment (MCI).MethodsIn this single-center ...
Danming Xu, Xiaochu Wu, Junming Dai, Qing Li, Zhi Wang, Yimin Huang, Yu Zhang, Junjie Cao, Bingxue Li, Yirong Dong, Yanhao Tu   +10 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Characterization of NMDAR-independent learning in the hippocampus.

Frontiers in Behavioral Neuroscience, 2011
It is currently thought that memory formation requires the activation of NMDA receptors (NMDARs) in the hippocampus. However, recent studies indicate that these receptors are not necessary for all forms of learning. The current experiments examine this
Kaycie Kuss Tayler, Elizabeth eLowry, Kazumasa eTanaka, Brynne eLevy, Leon eReijmers, Mark eMayford, Brian J Wiltgen   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The The Effect of an Off-Feet Conditioning Protocol on Performance and Training Load Response to Intermittent Sprint Training Compared to an Equivalent Running Based Protocol

International Journal of Strength and Conditioning
Training for maximal intensity actions can lead to muscle damage, muscle soreness, and neuromuscular fatigue if not carefully managed.  Due to this potential impact, coaches sometimes look to off-feet conditioning (OFC) as an alternative.
Timothy Rogers, Ryan Connell, Jarrod Free, Nicholas Gill, Kim Hebert-Losier, Martyn Beaven   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Experimental Study of Mobile Air Conditioning System Transient Behavior [PDF]

, 1996
An experimental study of the the transient behavior of an automobile arr conditioning system was performed. The experiments were conducted on an original equipment air conditioning system modified for laboratory investigation. Qualitative results showing
Collins, C.D., Miller, N.R.
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Testing Portfolio Efficiency with Conditioning Information [PDF]

We develop asset pricing models' implications for portfolio efficiency when there is conditioning information in the form of a set of lagged instruments.
Wayne E. Ferson, Andrew F. Siegel
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