Results 81 to 90 of about 433,153 (315)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

IJSC Community Review Announcement

International Journal of Strength and Conditioning, 2021
International Journal of Strength and Conditioning
doaj   +1 more source

Characterization of NMDAR-independent learning in the hippocampus.

Frontiers in Behavioral Neuroscience, 2011
It is currently thought that memory formation requires the activation of NMDA receptors (NMDARs) in the hippocampus. However, recent studies indicate that these receptors are not necessary for all forms of learning. The current experiments examine this
Kaycie Kuss Tayler, Elizabeth eLowry, Kazumasa eTanaka, Brynne eLevy, Leon eReijmers, Mark eMayford, Brian J Wiltgen   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The The Effect of an Off-Feet Conditioning Protocol on Performance and Training Load Response to Intermittent Sprint Training Compared to an Equivalent Running Based Protocol

International Journal of Strength and Conditioning
Training for maximal intensity actions can lead to muscle damage, muscle soreness, and neuromuscular fatigue if not carefully managed.  Due to this potential impact, coaches sometimes look to off-feet conditioning (OFC) as an alternative.
Timothy Rogers, Ryan Connell, Jarrod Free, Nicholas Gill, Kim Hebert-Losier, Martyn Beaven   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Stress effects on working memory, explicit memory, and implicit memory for neutral and emotional stimuli in healthy men

Frontiers in Behavioral Neuroscience, 2009
Stress is a strong modulator of memory function. However, memory is not a unitary process and stress seems to exert different effects depending on the memory type under study.
Mathias Luethi, Beat Meier, Carmen Sandi
doaj   +1 more source

Testing Portfolio Efficiency with Conditioning Information [PDF]

We develop asset pricing models' implications for portfolio efficiency when there is conditioning information in the form of a set of lagged instruments.
Wayne E. Ferson, Andrew F. Siegel
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