Results 101 to 110 of about 433,153 (315)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The influence of classical-conditioning procedures on subsequent attention to the conditioned brand. [PDF]
Three experiments are used to investigate the influence of conditioning procedures on attention to a conditioned stimulus. In experiment 1, scenes presented in a sequence that is consistent with prescribed conditioning procedures are shown to encourage ...
Janiszewski, C, Warlop, Luk
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
[Air-conditioning layout : 32 Hall Street, Hawthorn]
, 1976 Commercial; office; warehouse; diagramPhysical format : thick stock paper; 600x420mmEng. By N.L.B. ; Drawn by B.E.SConn-Australia, Montida Nominees Pty Ltd 32 Hall Street, Hawthorn. Architect: H.E.
Thomas Air Conditioning
core
The application of classical conditioning to the machine learning of a commonsense knowledge of visual events [PDF]
, 2013 In the field of artificial intelligence, possession of commonsense knowledge has long been considered to be a requirementto construct a machine that possesses artificial general intelligence.
Furze, Timothy Andrew
core
Conditions on conditional mood [PDF]
Acta Linguistica Hungarica, 2006 This paper argues that conditional mood morphology in Hungarian is the spellout of a morphosyntactic feature excl(w), the semantic interpretation of which is modal exclusion, i.e., counterfactuality. In certain cases (such as wishes, or CF conditionals) this feature is lexically specified on M[ood], with the direct interpretive aim of counterfactuality,
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Glasgow Mathematical Journal, 2017 AbstractThis paper is about the connection between certain Banach-algebraic properties of a commutative Banach algebra E with unit and the associated commutative Banach algebra C(X, E) of all continuous functions from a compact Hausdorff space X into E. The properties concern Ditkin's condition and bounded relative units.
Nikou, Azadeh, O'Farrell, Anthony G.
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source