Results 101 to 110 of about 514,614 (257)

Heating, ventilating, air-conditioning guide.

open access: yes
Vols. for 1922-37 issued as Guide of the American Society of Heating and Air-Conditioning Engineers under its earlier name.Vols. for 1922-59 published by the American Society of Heating and Air-Conditioning Engineers (called 1922-54, American Society of ...
American Society of Heating, Refrigerating and Air-Conditioning Engineers   +2 more
core  

Bayesian Optimization of Electrode Conditioning of Ni(‐Fe) Electrodes for the Alkaline Oxygen Evolution Reaction

open access: yesChemElectroChem
Efficient alkaline water electrolysis requires highly active electrodes for the sluggish oxygen evolution reaction (OER). NiFeOxHy materials are among the most active OER electrocatalysts, and their activity can be tailored, among other methods, by ...
J. Raphael Seidenberg   +6 more
doaj   +1 more source

COMPASS Guidelines for Conducting Welfare-Focused Research into Behaviour Modification of Animals

open access: yesAnimals
Researchers are increasingly engaged in studies to determine and correct negative welfare consequences of animal husbandry and behaviour modification procedures, not least in response to industries’ growing need to maintain their social licence through ...
Paul D. McGreevy   +21 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Air Conditioning Hybrid Electric Vehicles while Stopped in Traffic [PDF]

open access: yes, 2004
HEVs idle their engine during the stops to meet the cooling and heating needs. But, idling decreases fuel economy and increases engine wear and emissions.
T. Malik   +3 more
core  

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