Results 111 to 120 of about 514,614 (257)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Sex differences in fear conditioning in posttraumatic stress disorder

European Journal of Psychotraumatology, 2012
Rationale/statement of the problem: Women are twice as likely as men to develop Posttraumatic stress disorder (PTSD). Abnormal acquisition of conditioned fear has been suggested as a mechanism for the development of PTSD.
Sabra S. Inslicht, Thomas J. Metzler, Mohammed Milad, Suzanne Pineles, Scott Orr, Charles Marmar, Thomas C. Neylan   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Dynamic Modeling of a Mobile Air Conditioning Compressor and Condenser from Actual Performance Data [PDF]

, 1992
Submitted by Megan Hayes (mohayes2@illinois.edu) on 2009-03-06T03:20:40Z No. of bitstreams: 1 TR012.pdf: 3790017 bytes, checksum: 1a6a806106488e193c33c2f7e8b483e9 (MD5)Made available in DSpace on 2009-03-06T03:20:40Z (GMT). No. of bitstreams: 1 TR012.pdf:
Knobloch, L.A.
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dynamic Conditioning and Credit Correlation Baskets [PDF]

Dynamic conditioning is a technique that allows one to formulate correlation models for large baskets without incurring in the curse of dimensionality. The individual price processes for each reference name can be described by a lattice model specified ...
Vidler, Alicia, Albanese, Claudio
core  

Investigation of Control Strategies for Reducing Mobile Air Conditioning Power Consumption [PDF]

, 2002
Submitted by Megan Hayes (mohayes2@illinois.edu) on 2009-06-04T22:06:56Z No. of bitstreams: 1 TR199.pdf: 1603348 bytes, checksum: cc23a1753bf1fe92f8c174b5bd35783d (MD5)Made available in DSpace on 2009-06-04T22:06:56Z (GMT). No. of bitstreams: 1 TR199.pdf:
Hrnjak, P.S., Miller, N.R., Alleyne, Andrew G., Dane, M.H., Bullard, C.W.   +4 more
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Dynamic Modeling of a Mobile Air Conditioning System From Actual Performance Data [PDF]

, 1992
Made available in DSpace on 2009-03-06T02:38:09Z (GMT). No. of bitstreams: 1 TR010.pdf: 3850427 bytes, checksum: 72783207f64bb340b2ec6507d3fef3ac (MD5) Previous issue date: 1992-01Submitted by Megan Hayes (mohayes2@illinois.edu) on 2009-03-06T02:38 ...
Schenk, C.R.
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source