Results 91 to 100 of about 112,621 (302)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Evolução dos conhecimentos, atitudes e práticas relativas ao HIV/Aids em uma população de favela do Rio de Janeiro

Cadernos de Saúde Pública
O estudo visa acessar o estágio atual de conhecimentos, atitudes e comportamentos relativos ao HIV/Aids na população da favela da Rocinha, a qual vem sendo abrangida por um programa de controle há 6 anos. Foram entrevistados 210 moradores com idade entre
João Claudio Lara Fernandes
doaj  

Birds, Bees and Bias: How Absent Sex Ed Standards Fail New York's Students [PDF]

, 2012
Many public school districts across New York State provide sex-ed instruction that is inaccurate, incomplete and biased, according to Birds, Bees and Bias: How Absent Sex Ed Standards Fail New York's Students.
Alison Yager, Esther Lok, Johanna Miller, Kat Noel, Melissa Goodman, Rachel Santamaria-Schwartz   +5 more
core  

The hiv stigma: duty or defence? [PDF]

, 2015
: This article will outline and analyse the current stance of English criminal law regarding the transmission of HIV. The issues that surround consent, particularly in circumstances involving HIV, will be examined in conjunction with the defence of ...
Harker, Kate, Wright, Ellen
core   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

Qualitative impact assessment of an educational workshop on primary care practitioner attitudes to NICE HIV testing guidelines

BJGP Open, 2018
Background: In 2013, Public Health England piloted the ‘3Cs (chlamydia, contraception, condoms) and HIV (human immunodeficiency virus)’ educational intervention in 460 GP surgeries. The educational HIV workshop aimed to improve the ability and confidence
Rosalie L Allison, Ellie J Ricketts, Thomas Hartney, Anthony Nardone, Katy Town, Claire Rugman, Kate Folkard, J Kevin Dunbar, Cliodna AM McNulty   +8 more
doaj   +1 more source

Contraception as a Sex Equality Right [PDF]

, 2015
Challenges to federal law requiring insurance coverage of contraception are occurring on the eve of the 50th Anniversary of the U.S. Supreme Court’s decision in Griswold v. Connecticut.
Siegel, Neil S., Siegel, Reva B.
core   +2 more sources

Factors associated with not testing for HIV and consistent condom use among men in Soweto, South Africa. [PDF]

, 2013
BackgroundBesides access to medical male circumcision, HIV testing, access to condoms and consistent condom use are additional strategies men can use to prevent HIV acquisition. We examine male behavior toward testing and condom use.ObjectiveTo determine
Coates, Thomas J, Dietrich, Janan, Gray, Glenda, Mhlongo, Sakhile, Otwombe, Kennedy N, Robertson, Gavin   +5 more
core   +3 more sources