Results 71 to 80 of about 11,831,950 (329)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

-5 Disruptive, Impulse Control, and Conduct Disorders

open access: yes, 2023
The assessment of oppositional defiant disorder, conduct disorder, antisocial personality disorder, and intermittent explosive disorder—the Disruptive, Impulse Control and Conduct Disorders—can be affected by biases in clinical judgment, including ...
Jeffrey D. Burke   +9 more
core   +1 more source

Conduct Disorder

open access: yes, 2017
Decades of research has shown that youths with conduct disorder (CD) represent a highly heterogeneous population. Over the past 20 years, most of the research and clinical work have focused on two sub-typing approaches to characterize the heterogeneity within CD: (1) the age of onset distinction introduced in DSM-IV and (2) the presence of callous ...
Clanton, Roberta L.   +3 more
  +5 more sources

Adjudications and self-harm in prisons during COVID-19: three-year longitudinal analysis of the Offender Personality Disorder Pathway in England and Wales

open access: yesBJPsych Open
Background The effects of pandemic-related restrictions on people in prisons who tend to have multiple complex health needs are not well understood. Aims We aimed to measure changes in adjudications and self-harm among people in prisons before and ...
Steven M. Gillespie   +8 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Do historical changes in parent-child relationships explain increases in youth conduct problems?

open access: yes, 2011
The coincidence of historical trends in youth antisocial behavior and change in family demographics has led to speculation of a causal link, possibly mediated by declining quality of parenting and parent-child relationships. No study to date has directly
Collishaw, Stephan   +9 more
core   +1 more source

Chronological relationship between antisocial personality disorder and alcohol dependence [PDF]

open access: yes, 2002
Personality disorders, and particularly antisocial personality disorder (ASPD), frequently co-occur with alcohol dependence. ASPD is considered to be an important cofactor in the pathogenesis and clinical course of alcohol dependence.
Preuss, Ulrich W.   +2 more
core   +1 more source

Conduct Disorder: An Update

open access: yesPsikiyatride Güncel Yaklaşımlar
Conduct disorder is a serious mental disorder with a heterogeneous etiology that is frequently encountered in child and adolescent psychiatric clinics, although there are social and international differences.
Ahmet Özbay   +2 more
doaj   +1 more source

Long-Term Outcome of ADHD

open access: yesPediatric Neurology Briefs, 1998
The adult outcome of hyperactive boys with attention deficit hyperactivity disorder was evaluated by prospective follow-up and direct psychiatric interviews of 85 probands and 73 comparison subjects at the Child and Adolescent Behavior Center, Long ...
J Gordon Millichap
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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