Results 41 to 50 of about 85,461 (300)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Noncovalent functionalisation of polyaniline with the ionic liquid: An unneeded asset to prepare the emeraldine salt form of polyaniline using protic ionic liquids as polymerisation medium

eXPRESS Polymer Letters
Since the properties of polyaniline (PANI) are widely related to the type of its dopant, the present manuscript has an objective to define whether and to what extent the protic ionic liquids contribute to doping PANI.
Fatima Al-Zohbi, Fouad Ghamouss, Bruno Schmaltz, Mohamad Fadel Tabcheh, Mohamed Abarbri, Khalil Cherry, Mustapha Zaghrioui, François Tran-Van   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Tailored wrinkles for tunable sensing performance by stereolithography

Interdisciplinary Materials
Conducting polymer hydrogel can address the challenges of stricken biocompatibility and durability. Nevertheless, conventional conducting polymer hydrogels are often brittle and weak due to the intrinsic quality of the material, which exhibits ...
Ruiyi Jiang, Jie Pu, Yuxuan Wang, Jipeng Chen, Gangwen Fu, Xue Chen, Jiayu Yang, Jianghua Shen, Xing Sun, Jun Ding, Xi Xu   +10 more
doaj   +1 more source

Characterization of Composite Mesoporous Carbon/Conducting Polymer Electrodes Prepared by Chemical Oxidation of Gas-Phase Absorbed Monomer for Electrochemical Capacitors

International Journal of Electrochemical Science, 2011
Mesoporous carbon/conducting polymer composites have been synthesized by adsorption of different monomers (aniline, pyrrole, thiophene and 3-methyltiophene) in the gas phase onto the carbon surface, followed by oxidative chemical polymerization.
D.E. Pacheco-Catalán, Mascha A. Smit, E. Morales   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Developments in the Field of Conducting and Non-conducting Polymer Based Potentiometric Membrane Sensors for Ions Over the Past Decade

Sensors, 2008
Many research studies have been conducted on the use of conjugated polymers in the construction of chemical sensors including potentiometric, conductometric and amperometric sensors or biosensors over the last decade.
Mohammad Reza Ganjali, Rassoul Dinarvand, Parviz Norouzi, Farnoush Faridbod   +3 more
doaj  

Comparative Study on the Effect of Protonation Control for Resistive Gas Sensor Based on Close-Packed Polypyrrole Nanoparticles

Applied Sciences, 2020
Conducting polymers are often used as sensor electrodes due to their conjugated chain structure, which leads to high sensitivity and rapid response at room temperature.
Wooyoung Kim, Sunghun Cho, Jun Seop Lee
doaj   +1 more source