Results 41 to 50 of about 72,515 (262)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Noncovalent functionalisation of polyaniline with the ionic liquid: An unneeded asset to prepare the emeraldine salt form of polyaniline using protic ionic liquids as polymerisation medium

eXPRESS Polymer Letters
Since the properties of polyaniline (PANI) are widely related to the type of its dopant, the present manuscript has an objective to define whether and to what extent the protic ionic liquids contribute to doping PANI.
Fatima Al-Zohbi, Fouad Ghamouss, Bruno Schmaltz, Mohamad Fadel Tabcheh, Mohamed Abarbri, Khalil Cherry, Mustapha Zaghrioui, François Tran-Van   +7 more
doaj   +1 more source

μSR of conducting and non-conducting polymers

Physica B: Condensed Matter, 2000
Abstract μSR has been used to study a variety of polymers with very different electronic properties. In conducting polymers, the muon-generated radical states take the form of highly mobile polarons. Muon spin relaxation has been used to study the mobility of these polarons and to measure the temperature dependence of their intra-chain and inter ...
Pratt, F, Blundell, S, Jestädt, T, Lovett, B, Husmann, A, Marshall, I, Hayes, W, Monkman, A, Watanabe, I, Nagamine, K, Martin, R, Holmes, AB   +11 more
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Tailored wrinkles for tunable sensing performance by stereolithography

Interdisciplinary Materials
Conducting polymer hydrogel can address the challenges of stricken biocompatibility and durability. Nevertheless, conventional conducting polymer hydrogels are often brittle and weak due to the intrinsic quality of the material, which exhibits ...
Ruiyi Jiang, Jie Pu, Yuxuan Wang, Jipeng Chen, Gangwen Fu, Xue Chen, Jiayu Yang, Jianghua Shen, Xing Sun, Jun Ding, Xi Xu   +10 more
doaj   +1 more source

Characterization of Composite Mesoporous Carbon/Conducting Polymer Electrodes Prepared by Chemical Oxidation of Gas-Phase Absorbed Monomer for Electrochemical Capacitors

International Journal of Electrochemical Science, 2011
Mesoporous carbon/conducting polymer composites have been synthesized by adsorption of different monomers (aniline, pyrrole, thiophene and 3-methyltiophene) in the gas phase onto the carbon surface, followed by oxidative chemical polymerization.
D.E. Pacheco-Catalán, Mascha A. Smit, E. Morales   +2 more
doaj   +1 more source

Soft, Conductive, and Anti‐Freezing Conducting Polymer Organohydrogels

Advanced Sensor Research, 2023
Soft and conductive materials are highly desirable for wearable electronics. In particular, anti‐freezing, long‐water retention, and highly conductive gels with Young's modulus matching that of biological tissues, show promise in bioelectronics.
Xin Zhou, Pierre Kateb, Floriane Miquet‐Westphal, Gregory A. Lodygensky, Fabio Cicoira   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Comparative Study on the Effect of Protonation Control for Resistive Gas Sensor Based on Close-Packed Polypyrrole Nanoparticles

Applied Sciences, 2020
Conducting polymers are often used as sensor electrodes due to their conjugated chain structure, which leads to high sensitivity and rapid response at room temperature.
Wooyoung Kim, Sunghun Cho, Jun Seop Lee
doaj   +1 more source