Results 51 to 60 of about 155,553 (296)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Poly(o-methoxyaniline) modified electrode for detection of lithium ions

open access: yesQuímica Nova, 2012
This paper reports the use of an electrode modified with poly(o-methoxyaniline) for detecting lithium ions. These ions are present in drugs used for treating bipolar disorder and that requires periodical monitoring of the concentration of lithium in ...
Cleber Antonio Lindino   +3 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Conducting Polymers Functionalized with Phthalocyanine as Nitrogen Dioxide Sensors

open access: yesSensors, 2002
The conducting polymers such as polyaniline, polypyrrole and polythiophene were functionalized with copper phthalocyanine using chemical oxidation method. The obtained polymers viz.
S. D. Deshpande, S. Radhakrishnan
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

Conducting polymer-hydrogels for medical electrode applications

open access: yesScience and Technology of Advanced Materials, 2010
Conducting polymers hold significant promise as electrode coatings; however, they are characterized by inherently poor mechanical properties. Blending or producing layered conducting polymers with other polymer forms, such as hydrogels, has been proposed
Rylie A Green, Sungchul Baek, Laura A Poole-Warren and Penny J Martens
doaj  

Conducting polymers in biosensing: A review

open access: yesChemical Physics Impact
Medical diagnostics and, to a lesser extent, pharmacy is two of the most prominent applications of organic conducting polymers (CPs). Polymers that conduct electricity, such as polyaniline (PANI), polypyrrole (PPY), polythiophene (PTh), and poly (3, 4 ...
A.S. Bhattacharyya
doaj   +1 more source

Electrochemical Biosensors Based on Conducting Polymers: A Review

open access: yesApplied Sciences, 2020
Conducting polymers are an important class of functional materials that has been widely applied to fabricate electrochemical biosensors, because of their interesting and tunable chemical, electrical, and structural properties.
Boris Lakard
doaj   +1 more source

From non-degenerate conducting polymers to dense matter in the massive Gross-Neveu model

open access: yes, 2005
Using results from the theory of non-degenerate conducting polymers like cis-polyacetylene, we generalize our previous work on dense baryonic matter and the soliton crystal in the massless Gross-Neveu model to finite bare fermion mass.
E. T. Whittaker   +7 more
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

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