Results 101 to 110 of about 982,545 (278)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism

Frontiers in Physiology, 2019
AimSigma-1 receptors have been investigated and shown to play a protective role in both depression and cardiovascular disease. SA4503, known as a σ1 receptor agonist, regulates cardiac calcium and potassium channels in rat models of depression.
Xin Liu, Xin Liu, Xin Liu, Chuan Qu, Chuan Qu, Chuan Qu, Shaobo Shi, Shaobo Shi, Shaobo Shi, Tianxin Ye, Tianxin Ye, Tianxin Ye, Linglin Wang, Linglin Wang, Linglin Wang, Steven Liu, Steven Liu, Steven Liu, Cui Zhang, Cui Zhang, Cui Zhang, Jinjun Liang, Jinjun Liang, Jinjun Liang, Dan Hu, Dan Hu, Dan Hu, Bo Yang, Bo Yang, Bo Yang   +29 more
doaj   +1 more source

A Model of Heat Conduction

, 2008
We define a deterministic ``scattering'' model for heat conduction which is continuous in space, and which has a Boltzmann type flavor, obtained by a closure based on memory loss between collisions.
C.T. Ionescu Tulcea, J. -P. Eckmann, J.-P. Eckmann, J.-P. Eckmann, P. Collet, T. Kato   +5 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

TNFα Modulates Cardiac Conduction by Altering Electrical Coupling between Myocytes

Frontiers in Physiology, 2017
Background: Tumor Necrosis Factor α (TNFα) upregulation during acute inflammatory response has been associated with numerous cardiac effects including modulating Connexin43 and vascular permeability.
Sharon A. George, Patrick J. Calhoun, Robert G. Gourdie, Robert G. Gourdie, James W. Smyth, Steven Poelzing, Steven Poelzing   +6 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Corrigendum: The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism

Frontiers in Physiology, 2022
Xin Liu, Xin Liu, Xin Liu, Chuan Qu, Chuan Qu, Chuan Qu, Shaobo Shi, Shaobo Shi, Shaobo Shi, Tianxin Ye, Tianxin Ye, Tianxin Ye, Linglin Wang, Linglin Wang, Linglin Wang, Steven Liu, Steven Liu, Steven Liu, Cui Zhang, Cui Zhang, Cui Zhang, Jinjun Liang, Jinjun Liang, Jinjun Liang, Dan Hu, Dan Hu, Dan Hu, Bo Yang, Bo Yang, Bo Yang   +29 more
doaj   +1 more source