Results 31 to 40 of about 28,374 (314)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

MODERN ANESTHESIA STRATEGIES FOR PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY IN PATIENTS WITH CHRONIC LOWER LIMB ISCHEMIA

Клінічна та профілактична медицина
Introduction. Chronic lower limb ischemia represents a severe manifestation of peripheral arterial disease, associated with elevated risks of complications, disability, and mortality. Percutaneous transluminal angioplasty is a modern treatment option for
Vitalii S. Myrona, Volodymyr I. Cherniy, Oleh I. Nabolotnyi   +2 more
doaj   +1 more source

Comparison of the median and intermediate approaches to the ultrasound-guided sacral erector spinae plane block: a cadaveric and radiologic study [PDF]

Korean Journal of Anesthesiology
Background Erector spinae plane block (ESPB) is a well-established method for managing postoperative and chronic pain. ESPB applications for the sacral area procedures are called sacral ESPBs (SESPBs).
Bilge Olgun Keleş, Necati Salman, Elvan Tekir Yılmaz, Habip Resul Birinci, Alparslan Apan, Selami İnce, Ali Faruk Özyaşar, Aysun Uz   +7 more
doaj   +1 more source

Ultrasound-guided erector spinae plane block for open inguinal hernia repair: a randomized controlled trial

Brazilian Journal of Anesthesiology, 2022
Background and objectives: Inguinal hernia repair is associated with significant postoperative pain. We assessed the analgesia efficacy of unilateral Erector Spinae Plane block (ESP) performed under ultrasound guidance in patients submitted to open ...
Thiago Mamôru Sakae, Anna Paula Facco Mattiazzi, Joana Zulian Fiorentin, Julio Brandão, Roberto Henrique Benedetti, Augusto Key Karazawa Takaschima   +5 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Ilioinguinal and Iliohypogastric Nerve Blocks in Children

Central Asian Journal of Medical Sciences, 2017
Objectives: To examine ilioinguinal and iliohypogastric (ILIH) nerve block techniques among children. Methods: A total of 120 children, aged 1-16 years, were included in this prospective, randomized, single-blinded study.
Odgerel Boldbaatar, Ariuntungalag Maygmar, Ganchimeg Ayurzana, Ganbold Lundeg, Sergelen Orgoi   +4 more
doaj   +1 more source

General anesthesia or conscious sedation in paroxysmal atrial fibrillation catheter ablation

Biomedical Papers, 2021
Background. Catheter ablation of paroxysmal atrial fibrillation (AF) can be performed under general anesthesia or conscious sedation. The influence of type of anesthesiology care on procedural characteristics and ablation outcome in patients in whom ...
Ondrej Moravec, Tomas Skala, Olga Klementova, Jitka Skalova, Martin Hutyra, Jan Precek, Marian Fedorco, Vlastimil Cernicek, Zbynek Tudos, Jana Zapletalova, Milos Taborsky   +10 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Ultrasound-guided regional anesthesia for the pain management of elderly patients with hip fractures in the emergency department [PDF]

Clinical and Experimental Emergency Medicine, 2014
Objective We examined the pain-relieving effect of ultrasound-guided regional anesthesia performed by emergency physicians on elderly hip fracture patients. Methods This study is a prospective, non-randomized, case-control study.
Hee Kyung Lee, Bo Seung Kang, Chang Sun Kim, Hyuk Joong Choi   +3 more
doaj   +1 more source