Results 41 to 50 of about 27,482 (308)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Comparison of the median and intermediate approaches to the ultrasound-guided sacral erector spinae plane block: a cadaveric and radiologic study [PDF]

Korean Journal of Anesthesiology
Background Erector spinae plane block (ESPB) is a well-established method for managing postoperative and chronic pain. ESPB applications for the sacral area procedures are called sacral ESPBs (SESPBs).
Bilge Olgun Keleş, Necati Salman, Elvan Tekir Yılmaz, Habip Resul Birinci, Alparslan Apan, Selami İnce, Ali Faruk Özyaşar, Aysun Uz   +7 more
doaj   +1 more source

"CONDUCTIVE ANESTHESIA BY INTRASACRAL INJECTION OF PROCAIN" [PDF]

Journal of the American Medical Association, 1919
ABSTRACT To the Editor: —In The Journal, July 26, 1919, p. 298, appeared an abstract of an article of mine in the British Medical Journal, under the title of "Conductive Anesthesia by the Intrasacral Extradural Injection of Procain." Allow me to point out an inaccuracy in this abstract. I did not say that the method described is a new one.
openaire   +2 more sources

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

General anesthesia or conscious sedation in paroxysmal atrial fibrillation catheter ablation

Biomedical Papers, 2021
Background. Catheter ablation of paroxysmal atrial fibrillation (AF) can be performed under general anesthesia or conscious sedation. The influence of type of anesthesiology care on procedural characteristics and ablation outcome in patients in whom ...
Ondrej Moravec, Tomas Skala, Olga Klementova, Jitka Skalova, Martin Hutyra, Jan Precek, Marian Fedorco, Vlastimil Cernicek, Zbynek Tudos, Jana Zapletalova, Milos Taborsky   +10 more
doaj   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Ilioinguinal and Iliohypogastric Nerve Blocks in Children

Central Asian Journal of Medical Sciences, 2017
Objectives: To examine ilioinguinal and iliohypogastric (ILIH) nerve block techniques among children. Methods: A total of 120 children, aged 1-16 years, were included in this prospective, randomized, single-blinded study.
Odgerel Boldbaatar, Ariuntungalag Maygmar, Ganchimeg Ayurzana, Ganbold Lundeg, Sergelen Orgoi   +4 more
doaj   +1 more source

Ultrasound-guided regional anesthesia for the pain management of elderly patients with hip fractures in the emergency department [PDF]

Clinical and Experimental Emergency Medicine, 2014
Objective We examined the pain-relieving effect of ultrasound-guided regional anesthesia performed by emergency physicians on elderly hip fracture patients. Methods This study is a prospective, non-randomized, case-control study.
Hee Kyung Lee, Bo Seung Kang, Chang Sun Kim, Hyuk Joong Choi   +3 more
doaj   +1 more source

Carotid Endarterectomy under Regional (Conductive) Anesthesia

Annals of Surgery, 1982
Carotid endarterectomy is reliable in the prevention of strokes due to arteriosclerotic disease at the carotid bifurcation. This is a retrospective review of 314 carotid endarterectomies performed at the University Health Center of Pittsburgh. The objectives of the study were to determine if regional anesthesia was a safe technique for carotid ...
Jean-michel Loubeau, Marshall W. Webster, Andrew B. Peitzman, Henry T. Bahnson, Betty L. Grundy   +4 more
openaire   +4 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source