Results 91 to 100 of about 145,387 (305)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Non-equilibrium of Ionization and the Detection of Hot Plasma in Nanoflare-heated Coronal Loops

, 2008
Impulsive nanoflares are expected to transiently heat the plasma confined in coronal loops to temperatures of the order of 10 MK. Such hot plasma is hardly detected in quiet and active regions, outside flares.
Fabio Reale, Klimchuk J. A., Mewe R., Orlando S., Reale F., Salvatore Orlando, Serio S.   +6 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Regeneration efficiency, shuttle heat loss and thermal conductivity in epoxy-composite annualr gap regenerators from 4K to 80K [PDF]

, 1983
A test apparatus designed to simulate a section of a Stirling cycle cryocooler was built. Measurements of regeneration efficiency, shuttle heat loss and thermal conductivity reported for several regenerator test sections.
Cygax, S., Myrtle, K., Plateel, C., Winter, C.   +3 more
core   +1 more source

Feedback Heating by Cosmic Rays in Clusters of Galaxies

, 2007
Recent observations show that the cooling flows in the central regions of galaxy clusters are highly suppressed. Observed AGN-induced cavities/bubbles are a leading candidate for suppressing cooling, usually via some form of mechanical heating.
Berezinskii V. S., Fulai Guo, Ko C.-M., Kulsrud R. M., MacKenzie J. F., Mannheim K., Rephaeli Y., Reynolds C. S., S. Peng Oh, Schlickeiser R., Skilling J., Skilling J., Spitzer L., Voelk H. J., Volk H. J.   +14 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Band engineering in dilute nitride and bismide semiconductor lasers

, 2012
Highly mismatched semiconductor alloys such as GaNAs and GaBiAs have several novel electronic properties, including a rapid reduction in energy gap with increasing x and also, for GaBiAs, a strong increase in spin orbit- splitting energy with increasing ...
Broderick, CA, Broderick, CA, O'Reilly, EP, O'Reilly, EP, Sweeney, SJ, Usman, M   +5 more
core   +1 more source

Understanding conductivity and soda loss

TAPPI Journal, 2017
For more than 40 years, conductivity has been the inline measurement of choice for inferring black liquor/soda losses from brownstock washing. If properly applied, conductivity can provide a benefit in tracking changes in black liquor filtrate concentration.
Michael Brown, Peter W. Hart
openaire   +1 more source