Results 161 to 170 of about 23,210,949 (362)

The Experimental Studies on the Stimulus Conduction of the Interatrial Septum and it's Circumferences, Particulary the Sino-Tawara System (II) : CUTTING EXAMINATION AT THE INTERATRIAL SEPTUM AND IT'S CIRCUMFERENCE

, 1959
Yoshio Tateishi
openalex   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

His bundle pacing. Technical aspects and evidence base for use as an alternative to cardiac resynchronization therapy and conventional electrical pacing

Российский кардиологический журнал
His bundle pacing is a direct pacing of the specialized His-Purkinje conduction system with the aim of physiological ventricular activation, in contrast to the dyssynchronous activation by conventional myocardial pacing.In this review article on His ...
S. N. Krivolapov, M. V. Gorev, Yu. Yu. Gulyaev, M. S. Khlynin, R. E. Batalov   +4 more
doaj   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

EXPERIMENTAL INVESTIGATION ON THE MECHANICAL VIBRATING TRANSMISSION OF THE SOUND CONDUCTION SYSTEM IN THE MIDDLE EAR BY THE ELECTRICAL COCHLEAR RESPONSE

, 1951
J. UKIDA
openalex   +2 more sources

Numerical Solution of a parabolic system with blowup of the solution

, 2009
In this paper, the author proposes a numerical method to solve a parabolic system of two quasilinear equations of nonlinear heat conduction with sources. The solution of this system may blow up in finite time.
Roux, Marie-Noëlle Le
core   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Electron Microscope Studies on the Cardiac Conduction System of the Dog

, 1961
Keishiro Kawamura
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RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Variations of Aberrant Ventricular Conduction in Man: Evidence of Isolated and Combined Block Within the Specialized Conduction System

, 1968
Stafford I. Cohen, Sun H. Lau, Emanuel Stein, Melvin W. Young, Anthony N. Damato   +4 more
openalex   +1 more source