Results 171 to 180 of about 25,749,367 (326)

Editorial: Advancing our understanding of the cardiac conduction system to prevent arrhythmias. [PDF]

Front Physiol
Vigmond EJ, Bayer J.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Early perforation after attempted conduction system pacing: Lessons from the electrocardiogram. [PDF]

HeartRhythm Case Rep
Philippon F, Badreddine A, Gleeton D, Royer O, Bernier M, Borchani AA, Racine HP.   +6 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

When conduction system disease saves the day: A peculiar case of orthodromic pacemaker-mediated tachycardia. [PDF]

HeartRhythm Case Rep
Chopra N, Kumar S, Chaudhary S, Arora S, Ghati N.   +4 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Conduction system pacing in a congenital heart block patient with epicardial left ventricular pacing heart failure. [PDF]

Eur Heart J Case Rep
Perumalu K, Krishinan S, Krishinan S, Abdul Wahab MJ.   +3 more
europepmc   +1 more source

A CARDIAC CONDUCTION SYSTEM LOCALIZER

The Journal of Thoracic and Cardiovascular Surgery, 1964
W C, ZARNSTORFF, V L, GOTT, R C, DUTTON, G G, ROWE   +3 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Is conduction system pacing improving cardiac performance in patients with right bundle branch block and heart failure? [PDF]

Front Physiol
Jing-Jing J, Xi-Xia S, Tian-Zhu L, Xin W, Xiao-Lei Y, Xin-Jing A, Yun-Long X, Ying-Xue D.   +7 more
europepmc   +1 more source