Results 191 to 200 of about 25,749,367 (326)

Nkx2-5 Suppresses the Proliferation of Atrial Myocytes and Conduction System

Circulation Research, 2014
Yasuhiro Nakashima, Diana A. Yanez, Marlin Touma, H. Nakano, Artur Jaroszewicz, M. Jordan, M. Pellegrini, K. Roos, A. Nakano   +8 more
semanticscholar   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Conduction System vs Biventricular Pacing in Heart Failure: The PhysioSync-HF Randomized Clinical Trial.

JAMA Cardiol
Zimerman A, Dal Forno A, Rohde LE, Ternes CM, Alves FD, Damiani LP, Martinelli-Filho M, Costa R, Fagundes AA, Barbosa RM, Gadelha EB, Lima CE, Silva MA, Maldonado JA, de Oliveira JC, Mallmann F, Baggio Júnior JM, Duarte CE, de Souza LA, Santos JS, Silveira AD, Decker SRR, Zimerman LI, Polanczyk CA, d'Avila A.   +24 more
europepmc   +1 more source

Conduction system pacing using a rotatable connector enabling continuous pacing during lumenless lead deployment: a case report. [PDF]

Eur Heart J Case Rep
Montenegro Sá F, Castro A, Pereira S, Gavina C.   +3 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Conduction system in sudden death

Journal of the American College of Cardiology, 1987
openaire   +2 more sources

HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors

Circulation Research, 2013
Xingqun Liang, G. Wang, Lizhu Lin, J. Lowe, Qingquan Zhang, Lei Bu, Yihan Chen, Ju Chen, Yunfu Sun, S. Evans   +9 more
semanticscholar   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Radiation exposure and clinical validation of autosegmentation models for the supraventricular cardiac conduction system in breast cancer radiotherapy: an institutional perspective. [PDF]

Front Oncol
Zhang Y, Han X, Chi Z, Zhao Z, Wang F, Liu D, Han R.   +6 more
europepmc   +1 more source