Results 191 to 200 of about 226,605 (286)

Mathematical justification of a compressible two-phase averaged system for ideal gas without conduction: A semi-discrete approach and numerical illustrations [PDF]

P Gonin--Joubert
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Prevalence of cardiac fibrosis and infiltrative cardiomyopathy in patients with advanced conduction system disease. [PDF]

J Arrhythm
William J, Muthana H, Hogarty J, Taylor A, Hare JL, Mariani J, Patel H, Wong G, Stub D, Kaye DM, Prabhu S, Kistler PM, Voskoboinik A.   +12 more
europepmc   +1 more source

Transcriptional control of cardiac conduction system development and function

, 2020
Jan Hendrik van Weerd
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Triple transitions and QRS alternans with left bundle branch area pacing: Insights into conduction system pacing physiology

HeartRhythm Case Reports
Julia Herbert, Haran Burri, MD, FEHRA, FESC   +1 more
doaj   +1 more source

High-density mapping for AVNRT ablation with distorted conduction system anatomy post-ASD device closure-case report. [PDF]

Indian Pacing Electrophysiol J
Lahiri S, Baman M, Huibonhoa RM, Ferns S.   +3 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pacing of the specialized His Purkinje conduction system: 'HOW and FOR WHOM'. [PDF]

Eur Heart J Suppl
Chiarazzo E, Golia P, Bressi E, Grieco D, De Ruvo E, Calò L.   +5 more
europepmc   +1 more source