Results 111 to 120 of about 8,103,626 (315)

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Our Shared Responsibility to End Plastic Pollution, Protect Human Health, and Advance Social Justice for All

open access: yesJournal of Moral Theology
Continuing unchecked increases in plastic production are unethical and immoral. Moreover, continuing increases in plastic production and use are responsible for damages that threaten all forms of life on earth. Resolute international actions, including a
Conference Participants
doaj   +1 more source

The Unionization of Clerical Workers in Colleges and Universities: A Status Report [PDF]

open access: yes, 1989
[Excerpt] The 1980s have presented a myriad of problems for the labor movement as membership and bargaining power have declined in manufacturing, construction and transportation. Attempting to come to grips with the new reality of an economy dominated by
Hurd, Richard W
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Labor and Urban Crisis in Buffalo, New York: Building a High Road Infrastructure [PDF]

open access: yes, 2005
With inequality growing and competitive market forces on the march, can unions play a constructive role in solving the problems of capitalist economic development? Should they try?
Fleron, Lou Jean, Greer, Ian
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

High speed pressure learning in UK feature film units

open access: yes, 2005
The conference paper is available at http://neumann.hec.ca/aimac2005/PDF_Text/Ludwin_Linda.pdf. This conference paper is not available through the Chester Digital RepositoryThis conference paper discusses how UK film units (as temporary organisations ...
Ludwin, Linda
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

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