Results 61 to 70 of about 3,981,767 (279)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Official record : minutes of the ... session of the Des Moines Annual Conference of the Methodist Church. [PDF]
Some vols. include minutes of the quadrennial Lay Electoral Conferences.Title varies: -1875, Register of the ... session of the Des Moines Annual Conference; 1876- , Journal of the ...
Methodist Episcopal Church. Des Moines Conference.
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Research reports : 49th annual Pacific Northwest Vegetable Insect Conference [PDF]
Proceedings of the 49th Pacific Northwest Vegetable Insect Conference, held January 8-9, 1990 at the Imperial Hotel in Portland, Oregon.These are research reports only and should not be interpreted as recommendations of the conference.
Pacific Northwest Vegetable Insect Conference
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Minutes of the Wisconsin Annual Conference of the Methodist Episcopal Church [... session]. [PDF]
Held at various places.Title varies slightly: Minutes of the ... session of the Wisconsin Annual Conference of the Methodist Episcopal Church, 1851- 1866-1871; Minutes of the ...
Methodist Episcopal Church. Wisconsin Conference.
core
Journal of the Canadian Health Libraries Association, 2023 Alison Manley, Robin Parker
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Western Orchard Pest and Disease Management Conference : Conference abstracts : 77th annual conference [PDF]
Proceedings of the 77th Annual Western Orchard Pest and Disease Management Conference, held January 15-17, 2003 at the Hilton Portland in Portland ...
Western Orchard Pest and Disease Management Conference
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source