Results 61 to 70 of about 280,867 (260)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
IZVJEŠTAJ/CONFERENCE REPORT Izvještaj sa okruglog stola “HISTORIJSKI ZNAČAJ PRIJEMA REPUBLIKE BOSNE I I HERCEGOVINE U ČLANSTVO ORGANIZACIJE UJEDINJENIH NACIJA – 26 godina poslije”, Tuzla, 15. decembar 2018. godine [PDF]
Historijski pogledi, 2018 IZVJEŠTAJ/CONFERENCE REPORT Izvještaj sa okruglog stola “HISTORIJSKI ZNAČAJ PRIJEMA REPUBLIKE BOSNE I I HERCEGOVINE U ČLANSTVO ORGANIZACIJE UJEDINJENIH NACIJA – 26 godina poslije”, Tuzla, 15.
Adnan Tinjić
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Conference Report: CyberPunk Culture Conference 2020
Fafnir, 2020 Are we living in a cyberpunk future? As the calendar ticks onwards it inevitably collides with futures imagined by science-fiction authors. With its focus specifically on the near-future, cyberpunk is the first to be encountered, and on the 9th and 10th
Adam Edwards
doaj