Results 121 to 130 of about 2,666,927 (269)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Climate change risk communication: a vaccine hesitancy perspective

The Lancet Planetary Health, 2021
Pauline Paterson, Richard M Clarke
doaj   +1 more source

ANALISIS IKLAN SIMPATI DENGAN MENGGUNAKAN CONSUMER DECISION MODEL

Jurnal Ilmu Sosial, 2016
In order that position of a brand always engage in the mind of consumers, the company does not only act positioning strategy, but they have to give the right information about their product, and advertising on the television is one of the most effective ...
Reni Shinta Dewi
doaj  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Confidence in naturalistic decision making. [PDF]

Neurosci Conscious
Shekhar M, Cleeremans A, Rahnev D.
europepmc   +1 more source

Speed is Confidence

CoRR
Biological neural systems must be fast but are energy-constrained. Evolution's solution: act on the first signal. Winner-take-all circuits and time-to-first-spike coding implicitly treat when a neuron fires as an expression of confidence. We apply this principle to ensembles of Tiny Recursive Models (TRM) [Jolicoeur-Martineau et al., 2025].
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Through the Cultural Prism: The Influence of a Distinctive Chinese Personality-Junzi Personality-On Psychosocial Adjustment in China. [PDF]

Int J Psychol
Zhao B, Liu C, Muhetaer P, Hu P.
europepmc   +1 more source