Results 51 to 60 of about 3,781,470 (370)

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Confidence intervals: Concepts, fallacies, criticisms, solutions and beyond [PDF]

open access: yesNetwork Biology, 2022
For a long time, confidence interval theory is the basis of statistics, and confidence interval has been regarded as an important content of statistical analysis.
WenJun Zhang
doaj  

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

open access: yesMolecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang   +10 more
wiley   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

open access: yesMolecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang   +3 more
wiley   +1 more source

Evaluating COVID-19 in Portugal: Bootstrap confidence interval

open access: yesAIMS Mathematics
In this paper, we consider a compartmental model to fit the real data of confirmed active cases with COVID-19 in Portugal, from March 2, 2020 until September 10, 2021 in the Primary Care Cluster in Aveiro region, ACES BV, reported to the Public Health ...
Sofia Tedim   +5 more
doaj   +1 more source

An SPSS Macro to Compute Confidence Intervals for Pearson’s Correlation [PDF]

open access: yesTutorials in Quantitative Methods for Psychology, 2014
In many disciplines, including psychology, medical research, epidemiology and public health, authors are required, or at least encouraged to report confidence intervals (CIs) along with effect size estimates.
Bruce Weaver, Ray Koopman
doaj  

Fletcher-Turek Model Averaged Profile Likelihood Confidence Intervals [PDF]

open access: yesModel-averaged confidence intervals. Scandinavian Journal of Statistics, 43, 35-48 (2016), 2014
We evaluate the model averaged profile likelihood confidence intervals proposed by Fletcher and Turek (2011) in a simple situation in which there are two linear regression models over which we average. We obtain exact expressions for the coverage and the scaled expected length of the intervals and use these to compute these quantities in particular ...
arxiv   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu   +7 more
wiley   +1 more source

Becoming confident about confidence intervals [PDF]

open access: yesThe Bone & Joint Journal, 2017
A clear understanding of variability is at the heart of many of the studies published in The Bone & Joint Journal . The terms variability, dispersion, spread, distribution and variance, amongst others, are used to refer to the range of values within a dataset.
Perry, DC   +5 more
openaire   +3 more sources

Review of alternative approaches to calculation of a confidence interval for the odds ratio of a 2 × 2 contingency table

open access: yes, 2013
A common situation in biology is where we have count data and wish to explore whether there is an association between two categorical variables, each with two levels (a 2 × 2 contingency table).
G. Ruxton, M. Neuhäuser
semanticscholar   +1 more source

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