Results 51 to 60 of about 2,850,517 (328)

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

The P value and statistical significance: Misunderstandings, explanations, challenges, and alternatives

open access: yesIndian Journal of Psychological Medicine, 2019
The calculation of a P value in research and especially the use of a threshold to declare the statistical significance of the P value have both been challenged in recent years.
Chittaranjan Andrade
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Confidence Interval Estimation of Proportion Near Zero or One: A Modeling Secondary Study

open access: yesمجله اپیدمیولوژی ایران, 2017
Background and Objectives: When computing a confidence interval for a binomial proportion p, one must choose an exact interval that has a coverage probability of at least 1-α for all values of p.
S Hamzeh, AR Soltanian, J Faradmal
doaj  

Confidence intervals for the difference and the ratio of Lognormal means with bounded parameters [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2015
In this paper, confidence intervals for the difference between lognormal means and the ratio of lognormal means with restricted parameter spaces are proposed.
Sa-aat Niwitpong
doaj  

Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma

open access: yesBMC Bioinformatics, 2023
Background Over the past several decades, metrics have been defined to assess the quality of various types of models and to compare their performance depending on their capacity to explain the variance found in real-life data.
Evgueni Jacob   +8 more
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Common pitfalls in statistical analysis: "P" values, statistical significance and confidence intervals

open access: yesPerspectives in Clinical Research, 2015
In the second part of a series on pitfalls in statistical analysis, we look at various ways in which a statistically significant study result can be expressed.
Priya Ranganathan   +2 more
doaj   +1 more source

Twelve-Year Analysis of NO2 Concentration Measurements at Belisario Station (Quito, Ecuador) Using Statistical Inference Techniques

open access: yesSensors, 2020
In this paper, a robust analysis of nitrogen dioxide (NO2) concentration measurements taken at Belisario station (Quito, Ecuador) was performed. The data used for the analysis constitute a set of measurements taken from 1 January 2008 to 31 December 2019.
Wilmar Hernandez, Alfredo Mendez
doaj   +1 more source

Are P values given more importance than they deserve?

open access: yesEndodontology, 2023
In many of the scientific reports, the conclusions are based on the P values. The results are dichotomized based on the cutoff of P values. Often, the clinical significance is ignored over statistical significance.
Vivek Aggarwal, Mamta Singla
doaj   +1 more source

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