Results 71 to 80 of about 422,849 (261)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Confidence intervals: Concepts, fallacies, criticisms, solutions and beyond [PDF]
Network Biology, 2022 For a long time, confidence interval theory is the basis of statistics, and confidence interval has been regarded as an important content of statistical analysis.
WenJun Zhang
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A new confidence interval for the odds ratio
, 2023 We consider the problem of interval estimation of the odds ratio. An asymptotic confidence interval is widely applied in economics, medicine, sociology, etc.
Zielińska-Kolasińska, Zofia +1 more
core +1 more source
On the Bootstrap and Confidence Intervals
The Annals of Statistics, 1986 It is known that the bootstrap can be viewed as an empiric one term Edgeworth inversion. The present paper shows that such an inversion given by bootstrap is smooth and does not require preliminary theoretical calculations of the Edgeworth expansion.
openaire +3 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Confidence intervals for the difference and the ratio of Lognormal means with bounded parameters [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2015 In this paper, confidence intervals for the difference between lognormal means and the ratio of lognormal means with restricted parameter spaces are proposed.
Sa-aat Niwitpong
doaj
Comparisons of multivariate GR&R methods using bootstrap confidence interval
Acta Scientiarum: Technology, 2016 This paper aimed to compare the performance of multivariate GR&R (gage repeatability and reproducibility) studies based on PCA (principal component analysis) and Manova (multivariate analysis of variance) methods. To estimate the multivariate gauge index,
Rogério Santana Peruchi +4 more
doaj +1 more source
Confidence Trick: The Interpretation of Confidence Intervals [PDF]
Canadian Journal of Science, Mathematics and Technology Education, 2014 The frequent misinterpretation of the nature of confidence intervals by students has been well documented. This article examines the problem as an aspect of the learning of mathematical definitions and considers the tension between parroting mathematically rigorous, but essentially uninternalized, statements on the one hand and expressing imperfect but
openaire +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source