Results 61 to 70 of about 4,065,331 (316)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Confidence Interval Estimation of Proportion Near Zero or One: A Modeling Secondary Study

مجله اپیدمیولوژی ایران, 2017
Background and Objectives: When computing a confidence interval for a binomial proportion p, one must choose an exact interval that has a coverage probability of at least 1-α for all values of p.
S Hamzeh, AR Soltanian, J Faradmal
doaj  

A self‐normalized approach to confidence interval construction in time series [PDF]

, 2010
Summary.  We propose a new method to construct confidence intervals for quantities that are associated with a stationary time series, which avoids direct estimation of the asymptotic variances.
Xiaofeng Shao
semanticscholar   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Empirical methods for the validation of time-to-event mathematical models taking into account uncertainty and variability: application to EGFR + lung adenocarcinoma

BMC Bioinformatics, 2023
Background Over the past several decades, metrics have been defined to assess the quality of various types of models and to compare their performance depending on their capacity to explain the variance found in real-life data.
Evgueni Jacob, Angélique Perrillat-Mercerot, Jean-Louis Palgen, Adèle L’Hostis, Nicoletta Ceres, Jean-Pierre Boissel, Jim Bosley, Claudio Monteiro, Riad Kahoul   +8 more
doaj   +1 more source

Are P values given more importance than they deserve?

Endodontology, 2023
In many of the scientific reports, the conclusions are based on the P values. The results are dichotomized based on the cutoff of P values. Often, the clinical significance is ignored over statistical significance.
Vivek Aggarwal, Mamta Singla
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Confidence intervals for the difference and the ratio of Lognormal means with bounded parameters [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2015
In this paper, confidence intervals for the difference between lognormal means and the ratio of lognormal means with restricted parameter spaces are proposed.
Sa-aat Niwitpong
doaj  

Common pitfalls in statistical analysis: "P" values, statistical significance and confidence intervals

Perspectives in Clinical Research, 2015
In the second part of a series on pitfalls in statistical analysis, we look at various ways in which a statistically significant study result can be expressed.
Priya Ranganathan, C S Pramesh, Marc Buyse   +2 more
doaj   +1 more source

Confidence intervals: Concepts, fallacies, criticisms, solutions and beyond [PDF]

Network Biology, 2022
For a long time, confidence interval theory is the basis of statistics, and confidence interval has been regarded as an important content of statistical analysis.
WenJun Zhang
doaj