Results 91 to 100 of about 1,669,370 (251)

Assessing Confidence Intervals for the Tail Index by Edgeworth Expansions for the Hill Estimator [PDF]

AMS classifications: 62G20, 62G32;asymptotic normality;confidence intervals;Edgeworth expansions;extreme value index;Hill estimator;regular variation;tail ...
Segers, J., Haeusler, E.
core  

Threshold estimates and confidence intervals.

, 2022
Threshold estimates and confidence intervals.
Su Wang (191010), Qiang Liu (166143), Yuwen Chen (7055768)   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Wrapping input–output multipliers in confidence intervals

Journal of Economic Structures
Input–output multipliers are typically calculated as point estimates of the Leontief quantity model. From the previous literature, they can also be estimated (and their confidence intervals) directly from establishments’/industries’ inputs and outputs ...
Robert Stehrer, José Manuel Rueda-Cantuche, Antonio F. Amores, David Zenz   +3 more
doaj   +1 more source

Confidence Intervals for Standardized Effect Sizes: Theory, Application, and Implementation [PDF]

The behavioral, educational, and social sciences are undergoing a paradigmatic shift in methodology, from disciplines that focus on the dichotomous outcome of null hypothesis significance tests to disciplines that report and interpret effect sizes and ...
Ken Kelley
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

On a linear method in bootstrap confidence intervals

Statistica, 2007
A linear method for the construction of asymptotic bootstrap confidence intervals is proposed. We approximate asymptotically pivotal and non-pivotal quantities, which are smooth functions of means of n independent and identically distributed random ...
Andrea Pallini
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Learning about confidence intervals with software R

Education in the Knowledge Society, 2013
This work was to study the feasibility of implementing a teaching method that employs software, in a Computational Mathematics course, involving students and teachers through the use of the statistical software R in carrying out practical work, such ...
Gariela Gonçalves, Luís Afonso, Marta Ferreira, Teresa Ferro, Maria M. Nascimento   +4 more
doaj  

Re-Examining Confidence Intervals for Ratios of Parameters

Econometrics
This paper considers the problem of constructing confidence intervals (CIs) for nonlinear functions of parameters, particularly ratios of parameters a common issue in econometrics and statistics.
Zaka Ratsimalahelo
doaj   +1 more source