Results 111 to 120 of about 1,198,652 (310)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Quantile Regression Estimates of Confidence Intervals for WASDE Price Forecasts

open access: yes
This study uses quantile regressions to estimate historical forecast error distributions for WASDE forecasts of corn, soybean, and wheat prices, and then compute confidence limits for the forecasts based on the empirical distributions.
Isengildina-Massa, Olga   +2 more
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Constructing two-sided simultaneous confidence intervals for multinomial proportions for small counts in a large number of cells

open access: yes
Confidence intervals for multinomial proportions are often constructed using large-sample methods that rely on expected cell counts of 5 or greater. In situations that give rise to a large number of categories, the cell counts may not be of adequate size
Warren L. May, William D. Johnson
core  

What If... ? Robust Prediction Intervals for Unbalanced Samples

open access: yes, 2005
A confidence interval is a standard way of expressing our uncertainty about the value of a population parameter. In survey sampling most methods of confidence interval estimation rely on “reasonable” assumptions to be true in order to achieve nominal ...
Chambers, R. L.
core  

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye   +11 more
wiley   +1 more source

Confidence intervals in stationary autocorrelated time series

open access: yes
In this study we examine in covariance stationary time series the consequences of constructing confidence intervals for the population mean using the classical methodology based on the hypothesis of independence. As criteria we use the actual probability
Halkos, George, Kevork, Ilias
core  

Energy Substitutability in Canadian Manufacturing: Econometric Estimation with Bootstrap Confidence Intervals [PDF]

open access: yes
This study provides estimates of the price and Morishima substitution elasticities between energy and non-energy inputs in two Canadian energy-intensive manufacturing industries: Primary Metal and Cement.
Yazid Dissou, Reza Ghazal
core  

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler   +20 more
wiley   +1 more source

Empirical Likelihood Confidence Intervals for ROC Curves with Missing Data

open access: yes, 2011
The receiver operating characteristic, or the ROC curve, is widely utilized to evaluate the diagnostic performance of a test, in other words, the accuracy of a test to discriminate normal cases from diseased cases.
An, Yueheng
core   +1 more source

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