Results 71 to 80 of about 3,449,680 (270)
, 2016 Assumption/guarantee contracts represent the basis for independent development of reusable components and their safety assurance within contract-based design. In the context of safety-critical systems, their use for reuse of safety assurance efforts has encountered some challenges: the need for evidence supporting the confidence in the contracts; and ...
Sljivo, Irfan +3 more
openaire +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
SOIL-STRUCTURE INTERACTION ANALYSES OF PILE SUPPORTED BUILDING FRAME
ASEAN Journal on Science and Technology for Development, 2017 The effect of the soil-structure interaction on the simple single storeyed and two bayed space frame resting on pile group of two piles with flexible cap is examined in this paper by resorting to more rational approach and realistic assumptions ...
H.S. Chore, R.K. Ingle
doaj +1 more source
Viral Marketing On Configuration Model [PDF]
, 2013 We consider propagation of influence on a Configuration Model, where each vertex can be influenced by any of its neighbours but in its turn, it can only influence a random subset of its neighbours. Our (enhanced) model is described by the total degree of
Blaszczyszyn, Bartlomiej, Gaurav, Kumar
core +3 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Rosette Central Configurations, Degenerate Central Configurations and Bifurcations [PDF]
Celestial Mechanics and Dynamical Astronomy, 2006 In this paper we find a class of new degenerate central configurations and bifurcations in the Newtonian $n$-body problem. In particular we analyze the Rosette central configurations, namely a coplanar configuration where $n$ particles of mass $m_1$ lie at the vertices of a regular $n$-gon, $n$ particles of mass $m_2$ lie at the vertices of another $n$-
Lei, J., Santoprete, M.
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
STUDY OF EXPERIMENTAL SAMPLES WITH DIFFERENT CONFIGURATIONS AT THE JOINTS COMPRESSIVE STRENGTH
Вестник Дагестанского государственного технического университета: Технические науки, 2016 The article marked the behavior of concrete under the action of water, the effect of moisture and water saturation on the performance and durability of concrete waterproofing; offered special configuration interface, allowing to increase the strength ...
E. N. Magomedova, M. M. Batdalov
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source