Results 71 to 80 of about 735,591 (268)
Innovative Trends in the Development of Modern Enterprise Management Systems [PDF]
Problemi EkonomikiThe article determines that the current period of global economic development is characterized by rapid technological, economic, and social transformations, which require the adaptation of enterprise management systems to new conditions.
Slastianykova Krystyna I. +1 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
SOIL-STRUCTURE INTERACTION ANALYSES OF PILE SUPPORTED BUILDING FRAME
ASEAN Journal on Science and Technology for Development, 2017 The effect of the soil-structure interaction on the simple single storeyed and two bayed space frame resting on pile group of two piles with flexible cap is examined in this paper by resorting to more rational approach and realistic assumptions ...
H.S. Chore, R.K. Ingle
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
STUDY OF EXPERIMENTAL SAMPLES WITH DIFFERENT CONFIGURATIONS AT THE JOINTS COMPRESSIVE STRENGTH
Вестник Дагестанского государственного технического университета: Технические науки, 2016 The article marked the behavior of concrete under the action of water, the effect of moisture and water saturation on the performance and durability of concrete waterproofing; offered special configuration interface, allowing to increase the strength ...
E. N. Magomedova, M. M. Batdalov
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Adjoint-based RCS surface sensitivity calculation for very large electrical size object
Defence TechnologyThe primary concern in stealth aircraft design is the very large electrical size objects. However, the computational and storage requirements of these objects present significant obstacles for current high-fidelity design methods, particularly when ...
Jun Deng +5 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source