Results 71 to 80 of about 739,183 (268)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Effect of Nanosecond Pulsed Dielectric Barrier Discharge Plasma Actuation on the Longitudinal Characteristics of Flying-Wing Aircraft

气体物理
To improve the longitudinal aerodynamic characteristics of flying-wing configuration aircraft, a numerical simulation study on flow control using nanosecond pulse dielectric barrier discharge （NSDBD） plasma was conducted.
Fengling GUO, Zhengke ZHANG, Jinsheng CAI, Qi ZHAI, Yongqiang TIAN   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Study on the Aeroelastic Characteristics of a Large-Span Joined-Wing Solar-Powered UAV

Aerospace
When a joined-wing configuration is applied to the design of solar-powered UAVs, the increasing span amplifies aeroelastic effects, while structure complexity poses greater challenges to computational effectiveness during the conceptual design phase ...
Xinyu Tong, Xiaoping Zhu, Zhou Zhou, Junlei Sun, Jian Zhang, Qiang Wang   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Heat Transfer Enhancement using Combined Microchannel with Vertical Rectangular Micro Fins

Nigerian Journal of Technological Development, 2023
This paper focuses on the numerical optimisation of a combined hybrid microchannel heat sink with rectangular solid fins. The axial length and volume are fixed, and external structure is allowed to vary. The simulation was performed on an elemental unit
N. Y. Godi
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A novel ultra-high-speed air-based Taylor–Couette apparatus for exploring narrow-gap flows in high-speed rotating machinery

Flow
We present the design, construction and initial experimental validation of the Northwestern Polytechnical University Taylor–Couette (NPU-TC) apparatus, specifically developed to explore turbulent Taylor–Couette flows under conditions relevant to ultra ...
Xi-Ran Liu, Xue-Jie Wang, Jia-Qi Ma, Xin Chen, Heng-Dong Xi   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source