Results 61 to 70 of about 474,935 (329)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Ana Corbalán and Ellen Mayock. Toward a Multicultural Configuration of Spain: Local Cities, Global Spaces. Madison: Fairleigh Dickinson UP, 2015. vii–xix + 211 pp.

Studies in 20th & 21st Century Literature, 2016
Review of Ana Corbalán and Ellen Mayock. Toward a Multicultural Configuration of Spain: Local Cities, Global Spaces . Madison: Fairleigh Dickinson UP, 2015. vii–xix + 211 pp.
Jennifer Brady
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Configuration Spaces of Manifolds with Boundary

, 2018
We study ordered configuration spaces of compact manifolds with boundary. We show that for a large class of such manifolds, the real homotopy type of the configuration spaces only depends on the real homotopy type of the pair consisting of the manifold ...
Campos, Ricardo, Idrissi, Najib, Lambrechts, Pascal, Willwacher, Thomas   +3 more
core   +2 more sources

On Configuration Space

, 2023
A particular class of real manifolds (Hermitian spaces) naturally model smooth, possibly complex n-spaces. We show how to realize such a space as a restriction of a super-smooth stack using a compass. We also discuss the classical relationship between iterated loop spaces and the configuration space of a particle.
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Handclap for Acoustic Measurements: Optimal Application and Limitations

Acoustics, 2020
Handclap is a convenient and useful acoustic source. This study aimed to explore its optimal application and limitations for acoustic measurements as well for other possible utilizations.
Nikolaos M. Papadakis, Georgios E. Stavroulakis   +1 more
doaj   +1 more source

Exploring visitors’ visual perception along the spatial sequence in temple heritage spaces by quantitative GIS methods: a case study of the Daming Temple, Yangzhou City, China

Built Heritage, 2023
The Daming Temple, built during 457–464 C.E., is one of the developing ancient temple heritage spaces located in Yangzhou city, P. R. China. Over the past 60 years, variation in visitors’ spatial perception along the tour routes in the temple has ...
Kai Zhou, Wenting Wu, Tianjie Li, Xiaoling Dai   +3 more
doaj   +1 more source

Mod p truncated configuration spaces

Journal of the Mathematical Society of Japan, 2004
The author studies the space \(E^{d}_{J}(X)\) of configurations of ordered \(n\)-tuples of unordered \(d\)-tuples of points in \(X\). The n-tuples satisfy a set of intersection conditions specified by \(J\). For example one result asserts the natural homotopy equivalence of \(\lim_{d\to \infty}E^{d}_{J}(\mathbb{R}^k)\) and \(\Omega_{0}^{k}\bigcup_{d ...
openaire   +3 more sources