Results 61 to 70 of about 5,004,125 (344)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Ultra-Low-Loss Hollow-Core Bragg Antiresonant Fiber With Super Bandwidth Transmission Window

IEEE Photonics Journal, 2022
A novel hollow-core antiresonant fiber with a Bragg structure is proposed. It is numerically simulated using a commercial finite element method, and optical properties of the fiber, such as mode field, confinement loss, and bend loss, are numerically ...
Changming Xia, Zhipeng Deng, Aoyan Zhang, Peng Cai, Zhifeng Mo, Jiantao Liu, Guiyao Zhou, Zhiyun Hou, Qingmao Zhang, Liang Guo   +9 more
doaj   +1 more source

Limits to the analogue Hawking temperature in a Bose-Einstein condensate [PDF]

, 2007
Quasi-one dimensional outflow from a dilute gas Bose-Einstein condensate reservoir is a promising system for the creation of analogue Hawking radiation.
C. Barceló, C. J. Pethik, C. M. Savage, J. J. García-Ripoll, S. Wüster   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Photonic Crystal Fiber–Based Surface Plasmon Resonance Sensor for Precise Biochemical Refractive Index Sensing

Photonics
In this work, a D-shaped Photonic Crystal Fiber (PCF) sensor with a detection range of 1.30–1.35 is proposed, including Gold (Au), Titanium Dioxide (TiO2), graphene, and a functionalized sensing region.
Lalit Garia, Rajeev Kumar, Chang-Won Yoon, Mangal Sain   +3 more
doaj   +1 more source

Nanoporous PMMA: A novel system with different acoustic properties [PDF]

, 2016
The acoustic properties of closed cell nanoporous and microporous poly(methyl methacrylate) (PMMA) foams have been well characterized, showing that nanoporous PMMA exhibit a different absorption coefficient and transmission loss behavior in comparison ...
Ballesteros Agudo, Alberto, Notario Collado, Belén, Pinto Sanz, Javier, Rodríguez Pérez, Miguel Ángel   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Azimuthal Fourier decomposition for loss analysis of hollow-core tube lattice fibers, Part II: Tube thickness variation effects

Results in Optics
The effect on confinement loss of thickness variations along the perimeter of the tubes composing the cladding of inhibited-coupling guiding Tube Lattice hollow-core fibers is investigated by using the Azimuthal Fourier Decomposition technique (developed
Federico Melli, Fabio Giovanardi, Kostiantyn Vasko, Lorenzo Rosa, Fetah Benabid, Luca Vincetti   +5 more
doaj   +1 more source

Overview of Charm Physics at RHIC [PDF]

, 2006
Heavy-quark production provides a sensitive probe of the gluon structure of nucleons and its modication in nuclei. It is also a key probe of the hot-dense matter created in heavy-ion collisions.
Leitch, M. J.
core   +3 more sources