Results 111 to 120 of about 132,626 (258)

Experimental study on impact fracture characteristics and energy dissipation law of coal under water confining pressure

open access: yes矿业科学学报
To investigate the actual dynamic fracture process and energy dissipation mechanisms of coal under triaxial loading conditions, a visual experimental study was conducted using a self-developed multi-field coupled Split Hopkinson Pressure Bar (SHPB ...
WANG Kai   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Fast Determination of Soil Behavior in the Capillary Zone Using Simple Laboratory Tests [PDF]

open access: yes, 2012
INE/AUTC 13 ...
Li, Lin, Lytton, Robert L., Xhang, Xiong
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Study on the Rheological Properties and Constitutive Model of Shenzhen Mucky Soft Soil [PDF]

open access: yes, 2014
In order to obtain the basic parameters of numerical analysis about the time-space effect of the deformation occurring in Shenzhen deep soft-soil foundation pit, a series of triaxial consolidated-undrained shear rheology tests on the peripheral mucky ...
Feng, Yan-bo   +4 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Plastic dilation rate characteristic of concrete confined with steel tube [PDF]

open access: yes, 2017
The use of external confining devices to confine concrete has become widely used. One of the purposes is to gain additional concrete strength and ductility.
Attard, Mario M.   +2 more
core  

Contact tribology also affects the slow flow behavior of granular emulsions

open access: yes, 2018
Recent work on suspension flows has shown that contact mechanics plays a role in suspension flow dynamics. The contact mechanics between particulate matter in dispersions should depend sensitively on the composition of the dispersed phase: evidently ...
Dijksman, Joshua A., Workamp, Marcel
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Synchronized oscillations and acoustic fluidization in confined granular materials

open access: yes, 2018
According to the acoustic fluidization hypothesis, elastic waves at a characteristic frequency form inside seismic faults even in the absence of an external perturbation.
Ciamarra, M. Pica   +3 more
core   +1 more source

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