Results 101 to 110 of about 23,904 (309)

Anisotropic Damage to Hard Brittle Shale with Stress and Hydration Coupling

Energies, 2018
Acoustic-wave velocities of shale rocks with different coring angles were tested by an acoustic-emission experiment under different confining pressures and soaking time of drilling fluid.
Junchuan Gui, Tianshou Ma, Ping Chen, Heyi Yuan, Zhaoxue Guo   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Stress–strain relationship of sandstone under confining pressure with repetitive impact

, 2021
: A series of triaxial repetitive impact tests were conducted on a 50-mm-diameter split Hopkinson pressure bar testing device to reveal the characteristics of dynamic stress–strain of sandstone under confining pressure, and the confining pressure in this
Zhou, Jian, Wang, Shiming, Xiong, Xianrui, Liu, Yunsi, Khandelwal, Manoj   +4 more
core   +1 more source

Seepage forces and confining pressure effects on piping erosion

, 2000
An experimental study of piping erosion is presented. Various artificial granular filter and base soil combinations are tested in a permeameter under variable confining pressures to determine the critical gradient where soil erodes through the filter ...
S S Tomlinson, Y P Vaid
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Effect of Confining Pressure on Mechanical and Energy Conversion Properties of Gas-Containing Coal under Loads

, 2022
Confining pressure is closely related to the deformation and failure characteristics of gas-containing coal and is one of the key factors for gas outburst-rockburst coupled dynamic disaster. Firstly, this paper briefly summarized the triaxial compression
Zhizhen Zhang, Xiaoji Shang, Feng Gao, Yixin Niu, Rui Zhou, Xingguang Liu   +5 more
core   +1 more source

Experimental investigation of the acoustic emission characteristics and failure modes of triaxial unloading confining pressure in deep limestone

工程科学学报
To clarify the mechanical destabilization and fracturing characteristics of deep limestone subjected to high-confining-pressure unloading, a series of triaxial tests with synchronous acoustic-emission (AE) monitoring was performed on standard limestone ...
Chaoqun CHU, Xingjia BAO, Shunchuan WU, Hejia CUI, Guang ZHANG   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Research on acoustic emission characteristics and mechanical properties of shale under uniaxial and conventional triaxial compression

Scientific Reports
In order to analyze the acoustic emission (AE) characteristics and mechanical properties of muddy shale under different stress conditions, uniaxial and conventional triaxial compression tests and AE tests were carried out through the MTS815 electro ...
Wenjie Wu, Chee-Ming Chan, Xiaopeng Su, Yilei Gu, Mingqing Liu, Weijia Shao   +5 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source