Results 141 to 150 of about 131,723 (308)

Experimental investigation on mechanical properties and permeability evolution law of frozen calcareous clay under fluid-solid coupling

Case Studies in Construction Materials
In the Huainan-Huaibei deep tundra mining project, groundwater seepage and complex geostress significantly challenge construction safety. To systematically investigate the mechanical properties and permeability evolution of frozen ground under coupled in-
Lei Chang, Yi Cao, Chuanxin Rong, Shouzhong Feng, Deyuan Kan, Jiyuan Deng, Lezhang Xing   +6 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Mechanical behavior and reloading reinforcement characteristics of fractured coal under low confining pressure. [PDF]

Sci Rep, 2023
Yang YM, Gu XB, Liu XJ, Lu B, Ding XJ, Zhao YQ, Zhang WL, Liu G.   +7 more
europepmc   +1 more source

Experimental Determination of Elastic Anisotropy of Berea Sandstone, Chicopee Shale and Chelmsford Granite [PDF]

, 1985
We use the ultrasonic transmission method to measure P-, SH-, and SV-wave velocities for Chelmsford Granite, Chicopee Shale, and Berea Sandstone in different directions up to 1000 bars confining pressure.
Coyner, Karl B., La, Tien-when, Toksoz, M. Nafi   +2 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Transport of micron-sized polyethylene particles in confined aquifer: Effects of size, aging, and confining pressure. [PDF]

Heliyon, 2023
Chen X, Wan Y, Jia J, Qiang X, Wu C.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Chemical Corrosion-Water-Confining Pressure Coupling Damage Constitutive Model of Rock Based on the SMP Strength Criterion. [PDF]

Materials (Basel), 2023
Chen Y, Tong H, Chen Q, Du X, Wang S, Pan Y, Dong Y, Ma H.   +7 more
europepmc   +1 more source

Triaxial compression tests on a crushable sand in dry and wet conditions [PDF]

, 2015
A calcareous sand from the Persian Gulf is subjected to a series of dry and fully drained saturated triaxial shear tests. The samples are prepared at relative densities of 65% and either left dry or saturated. They are consolidated to confining pressures
Haegeman, Wim, Van Impe, PO, Wils, L
core   +1 more source