Results 91 to 100 of about 103,216 (257)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Social Skills Rating System - Brazilian Version: New Exploratory and Confirmatory Factorial Analyses

Avances en Psicología Latinoamericana, 2014
This study aimed to verify the Factorial Structure of the Brazilian version of the Social Skills Rating System (SSRS-BR), with an extended sample of participants, and their subsequent Confirmatory Factor Analyses in another subset of data.
Lucas Cordeiro Freitas, Zilda Aparecida Pereira Del Prette   +1 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Exploratory and confirmatory factor analyses identify three structural dimensions for measuring physical function in community-dwelling older adults. [PDF]

PeerJ, 2023
Jiang G, Tan X, Wang H, Xu M, Wu X.
europepmc   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Rasch and Confirmatory Factor Analyses of the Arabic Version of the Diabetes Self-Management Scale (DSMS): An Intercultural Approach. [PDF]

Healthcare (Basel), 2022
Kaabi YA, Alshaikh NA, Jerah AA, Halawi MA, Habibullah MM, Abdelwahab SI.   +5 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Exploratory factor and confirmatory analyses of the polycystic ovary syndrome health-related quality of life questionnaire (PCOSQ-50)

Health and Quality of Life Outcomes
Background A condition-specific instrument is necessary to measure the health-related quality of life among those with polycystic ovary syndrome (PCOS), the most common chronic endocrinopathy among women.
Pamela J. Wright, Abbas S. Tavakoli, Robin M. Dawson   +2 more
doaj   +1 more source

Web based instruction attitude scale:Explanatory and confirmatory factor analyses

Journal of Human Sciences, 2007
Bu çalışmanın amacı, öğrencilerin web tabalı öğretim karşı tutumlarını belirlemeye yönelik Likert tipi bir tutum ölçeği geliştirmektir. Bu amacı gerçekleştirmek üzere 58 maddelik bir deneme formu hazırlanmış ve bu form Bilgi Üniversitesi’nin web tabanlı işletme yüksek lisans programında ...
Erdoğan, Yavuz, Bayram, Servet, Deniz, Levent   +2 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source