Results 161 to 170 of about 4,195,887 (419)

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

DEVELOPMENT AND PSYCHOMETRIC PROPERTIES OF ADVERSE CHILDHOOD EXPERIENCES SCALE FOR ADOLESCENTS

open access: yesPakistan Armed Forces Medical Journal, 2020
Objective: To develop a scale and establish psychometric properties to measure Adverse Childhood Experiences of Adolescents in Urdu language. Study Design: Cross sectional analytical study.
Maryam Riaz, Zaqia Bano
doaj  

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

open access: yesMolecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou   +13 more
wiley   +1 more source

Perceived Vulnerability to Disease Scale: Factorial structure, reliability, and validity in times of Portugal's COVID-19 pandemic lockdown [PDF]

open access: yesarXiv
The present study examines the factor structure of a Portuguese version of the Perceived Vulnerability to Disease Scale (PVD), designed to assess individual differences in chronic concerns about transmission of infectious diseases. Method: Data from a Portuguese convenience sample (n=1203), collected during the first Covid-19 pandemic lockdown. Results:
arxiv  

Confirmatory factor analysis of the Consumer Assessment of Health Plans Study (CAHPS) 1.0 core survey. [PDF]

open access: green, 2001
Grant N. Marshall   +4 more
openalex   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

open access: yesMolecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang   +10 more
wiley   +1 more source

Identifying of effective factors on job dissatisfaction of primary school teachers in Bojnord city (Factor Analysis research)

open access: yesSalāmat-i kār-i Īrān, 2017
Background and aims: Feel job satisfaction is the most basic components of mental health and an important factor in career success. The aim of this study was identify of effective factors on job dissatisfaction of primary school teachers of Bojnord city.
Tayebe Rahimi Pordanjani   +1 more
doaj  

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