Results 221 to 230 of about 417,168 (325)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Integrated validation of a cross-cultural emotional competence scale using Confirmatory Factor Analysis, Rasch Modeling and Exploratory Graph Analysis. [PDF]

MethodsX
Garzón-Umerenkova A, Alba M, Cendales B, Espinosa JC, Ariza J.   +4 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Consequences of academic disappointment inventory: confirmatory factor analysis, reliability and convergent validity. [PDF]

BMC Psychol
Çopur AS, Kökönyei G.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Psychometric validation of the addiction potential questionnaire among Iranian children aged 12-18 years using confirmatory factor analysis. [PDF]

Health Promot Perspect
Jafarnezhad A, Ghaem Maralani H, Sahraian A, Aryaie M, Hassanzadeh J.   +4 more
europepmc   +1 more source

Confirmatory factor analysis model of the needs assessment tool for colorectal cancer (NeAT-CC) using partial least square-structural equation modelling.

Nur Nadiatul Asyikin Bujang (22470013), Yek Ching Kong (22470016), Muthukkumaran Thiagarajan (22470019), April Camilla Roslani (8367699), Muhammad Radzi Abu Hassan (6476000), Matin Mellor Abdullah (22470022), Mehesinder Singh (22470025), Wan Zamaniah Wan Ishak (18222482), Awang Bulgiba (132202), Mahmoud Danaee (611442), Nirmala Bhoo-Pathy (132899)   +10 more
openalex   +1 more source

Psychometric properties of the Spanish version of the UPPS-P Impulsive Behavior Scale: A Rasch rating scale analysis and confirmatory factor analysis.

, 2015
Angelina Pilatti, Óscar M. Lozano, Melissa A. Cyders   +2 more
openalex   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source