Results 151 to 160 of about 4,205,966 (314)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Changing World Order and US-China Maritime Power Contestation in the Indo Pacific

NUST Journal of Social Sciences and Humanities
The grand chess board of world geopolitics has effectively been dominated by the U.S since past many decades, however, economic rise of China and resultant maritime power contestation with US is rapidly changing the status-quo within Indo Pacific Region.
Muhammad Zubair Cheema, Lubna Sunawar
doaj  

When a conflict of interest is not a conflict [PDF]

Nature, 2019
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Understanding the Associations Between Attachment Insecurity, Emotional Flooding, and Conflict Behaviors in Prenatal Couples. [PDF]

J Marital Fam Ther
Morgan SD, Woodin EM.
europepmc   +1 more source

Conflicts

, 2004
Collier, P, Hoeffler, A
openaire   +2 more sources

The Conflict over the Conflict [PDF]

, 2020
Kenneth S. Stern, Nadine Strossen
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

It Takes Two to Tango: The Interplay of Partners' Communicated Perspective-Taking, Positive Relational Experience During Conflict and Relationship Satisfaction in Young Adult Couples. [PDF]

J Marital Fam Ther
Emond M, Ramos B, Léonard F, Péloquin K, Daspe MÈ.   +4 more
europepmc   +1 more source

Coercion and its Effects : Evidence from the Israel-Palestine Conflict

, 2019
Counterinsurgency, state repression and other forms of coercion have multiple adverse effects. Although a state’s use of threats and force should deter an opposition group, these measures often stimulate resistance.
Hatz, Sophia
core