Results 131 to 140 of about 4,205,966 (314)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Liberal and Digital Peace-building: A Comparative Analysis
NUST Journal of International Peace and StabilityPatterns and trends keep changing with the commencement of each global political era, and peacebuilding is an evolving and continuous phenomenon.
Maria Saifuddin Effendi, Zulfiqar Ali
doaj +1 more source
Cocaleros. Violence, Drugs and Social Mobilization in the Post-Conflict Upper Huallaga Valley, Peru
, 2009 During Peru’s internal armed conflict (1980s-1990s) the Upper Huallaga Valley became one of the most violent theaters of conflict, with political violence and violent crime becoming causally related phenomena.
Political Conflict, Cultural Trauma and Social Reconstruction +2 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Managing Organizational Conflict [PDF]
The concept of conflict, being an outcome of behaviours, is an integral part of human life. Wherever there is a difference of opinion there are chances of conflict. Managing conflict effectively demands multifarious professional abilities and acumen.
Mitali PATHAK
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Rehabilitating Health Systems in Post-Conflict Situations [PDF]
Although baseline data for post-conflict situations are frequently unavailable, there is a clear deterioration in the health conditions of populations during and following conflict. Excess mortality and morbidity, displaced populations, and vulnerability
Garrett, Brinnon +2 more
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Re-examining the Environment-Conflict Linkage In What Way Can the Environment 'Cause' Conflict? [PDF]
, 2011 "This article will discuss exactly how the environment--and the various variables that have been considered under this label--might be understood to 'cause' conflict.
Clausen, Daniel
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