Results 81 to 90 of about 4,660,911 (297)

¿El retorno del leopardo? Patrimonialismo y crisis post-transición en la República Democrática del Congo

Relaciones Internacionales, 2007
El artículo ofrece una interpretación de las razones por las cuales, a pesar del proceso de paz iniciado en el 2003 en la República democrática del Congo, el país se sigue caracterizando por elevados niveles de violencia física y estructural.
Koen VLASSENROOT, Timothy RAEYMAEKERS
doaj  

Promoting a bundle of biofortified seeds and agricultural inputs in northeastern Nigeria

, 2023
Smallholder farmers in northeastern Nigeria face the triple threat of food insecurity, climate volatility, and conflict. Northeastern Nigeria has some of the highest levels of food insecurity in Nigeria.
Misra, Rewa; Amare, Mulubrhan; Ambler, Kate; Bamiwuye, Temilolu; Bloem, Jeffrey R.; Wagner, Julia, http://orcid.org/0000-0002-9052-5868 Amare, Mulubrhan; http://orcid.org/0000-0001-6277-0930 Ambler, Kate; https://orcid.org/0000-0002-4995-3043 Bloem, Jeffrey   +1 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Preferences Under Pressure : Conflict, Threat Cues and Willingness to Compromise

, 2020
Understanding how preferences are formed is a key question in the social sciences. The ability of agents to interact with each other is a prerequisite for well-functioning societies. Nevertheless, the process whereby the preferences of agents in conflict
Skoog, Eric
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Climate, Conflict and Coping Capacity : The Impact of Climate Variability on Organized Violence

, 2016
Understanding the conflict potential of climate variability is critical for assessing and dealing with the societal implications of climate change.
von Uexkull, Nina
core   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source