Results 101 to 110 of about 4,205,966 (314)

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Radiology in conflict: scoping review

Conflict and Health
The United Nations estimate a quarter of the global population currently lives in violent conflict zones. Radiology is an integral part of any healthcare system, providing vital information to aid diagnosis and treatment of a range of disease and injury.
Trisha Suji, Richard Sullivan, Gemma Bowsher   +2 more
doaj   +1 more source

Punitiveness and Devaluation among Social Work Gatekeepers

Social Work and Society, 2020
This paper analyses the connection between a punitive educational orientation and different negative prejudices in the context of group-focused enmity.
Johanna Pangritz, Wilhelm Berghan
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

States and Peoples in Conflict: Pillars, Forms, and Transformations in Conflict Studies

, 2020
This introduction presents an overview of the key concepts covered in the subsequent chapters of this book. The book surveys theoretical and empirical research on the origins, processes, patterns, and consequences of most forms and contexts of political ...
Lichbach, Mark, Grabosky, Peter, Stohl, Michael   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Conflict-related environmental degradation threatens the success of landscape recovery in some areas in Tigray (Ethiopia)

Ecology and Society
Armed conflicts can lead to environmental degradation, thereby threatening the basis of people’s livelihoods and well-being. Identifying areas where conflicts drive environmental degradation is important for designing effective recovery strategies, but ...
Henrike Schulte to Bühne, Eoghan Darbyshire, Teklehaymanot G. Weldemichel, Jan Nyssen, Doug Weir   +4 more
doaj   +1 more source

Climate change policy, conflict and transformative governance [PDF]

, 2013
Climate change is the behemoth of our age. It defies description, is too large to comprehend, and what we do understand about it is often terrifying. This is for many, a good reason to stop thinking about it or, like Scarlett O’Hara, decide to “think ...
Melissa Nursey-Bray
core