Results 101 to 110 of about 3,609,079 (306)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

S17B-Neoaves-Conflict-Region-Overlap-Whole-Concept-Resolution

, 2019
S17B Fig. Input visualization for the 2015./2014.Neoaves alignment, under whole-concept resolution, limited to the main conflict region.
Shizhuo, Yu, Franz, Nico M., Brown, Joseph W., Ludäscher, Bertram, Nico M. Franz (8027303), Joseph W. Brown (8028728), Yu Shizhuo (6373742), Musher, Lukas J., Lukas J. Musher (6368897), Bertram Ludäscher (479396)   +9 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Navigating the Complexities of Inter-Religious Peacebuilding: Implications for Theory and Practice

Religions
As conflict dynamics become complex and escalate globally, especially identity-based conflicts, we are witnessing an unprecedented shift in the Conflict Analysis and Resolution and Peacebuilding field toward contextually innovative and effective ...
Charles Kwuelum
doaj   +1 more source

Office of Student Conduct and Conflict Resolution Annual Report (2019-2020)

, 2020
University of Minnesota Duluth. Office of Student Conduct and Conflict Resolution. (2020). Office of Student Conduct and Conflict Resolution Annual Report (2019-2020).
University of Minnesota Duluth. Office of Student Conduct and Conflict Resolution
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Balancing risk and reward: exploring women’s transactional sexual relationships with Blessers in South Africa

Humanities & Social Sciences Communications
Transactional sexual relationships (TSRs) take varied forms, with research emphasizing TSRs’ inherent risks, primarily to women. In South Africa, Blessed relationships have emerged as a prominent type of TSR.
Gavin George, Leena Maqsood, Courtenay Sprague   +2 more
doaj   +1 more source

Climate change policy, conflict and transformative governance [PDF]

, 2013
Climate change is the behemoth of our age. It defies description, is too large to comprehend, and what we do understand about it is often terrifying. This is for many, a good reason to stop thinking about it or, like Scarlett O’Hara, decide to “think ...
Melissa Nursey-Bray
core  

Nonviolent Conflict Escalation

, 2016
Escalation of conflict is frequently deemed undesirable and problematic, as it is often assumed to refer to the escalation of violence. However, there exists a different form of escalation that we call "nonviolent conflict escalation." This occurs when ...
Johansen, Jorgen, Majken Jul Sørensen, Sørensen, Majken Jul,, Jørgen Johansen   +3 more
core   +1 more source