Results 111 to 120 of about 3,609,079 (306)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Kulturní StudiaTo challenge the notion of the Okinawan moai as a Rotating Saving and Credit Association, this article provides a short overview of the practice before reflecting on an interesting pattern.
Abel Polese
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Conflict Resolution in the European Neighbourhood: The Role of the EU as a Framework and as an Actor [PDF]
The European Union's neighbourhood is rife with secessionist conflicts. The Union's proximity and its magnetic power of attraction has created the potential for a constructive European involvement in these regions. An EU role can be two-fold.
Nathalie Tocci
core
S18B-Neoaves-Conflict-Region-Overlap-Split-Concept-Resolution
, 2019 S18B Fig. Input visualization for the 2015./2014.Neoaves alignment, under split-concept resolution, limited to the main conflict region.
Shizhuo, Yu +9 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Office of Student Conduct and Conflict Resolution Strategic Plan (2020-2021)
, 2020 University of Minnesota Duluth. Office of Student Conduct and Conflict Resolution. (2020). Office of Student Conduct and Conflict Resolution Strategic Plan (2020-2021).
University of Minnesota Duluth. Office of Student Conduct and Conflict Resolution
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source