Results 101 to 110 of about 5,663,674 (349)

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

open access: yesMolecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou   +11 more
wiley   +1 more source

Conflict of interest as a barrier to local accountability [PDF]

open access: yes
Using a specially designed lab-type experiment conducted in the field, we compare the willingness of head teachers, centrally appointed public servants, and community representatives to hold Ugandan primary school teachers to account.
Abigail Barr, Andrew Zeitlin
core  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Conflicto de intereses Conflict of interest

open access: yesRevista Colombiana de Obstetricia y Ginecología, 2007
La condición humana, en particular el narcisismo normal del adulto, favorece que clínicos, investigadores, miembros de comités de investigación, de asesores y de bioética, así como pares, editores y los industriales del sector de la salud, sean proclives
Santiago Barrios-Vásquez
doaj  

Conflicts of interest: The ethical viewpoint [PDF]

open access: yes
Conflicts of interest are a very widespread ethical problem which, precisely for that reason, deserves special attention, both from a legal viewpoint and from the point of view of ethics applied to organizations and professions.
Argandoña, Antonio
core  

Globalizing Savigny: The State in Savigny’s Private International Law, and the Challenge of Europeanization and Globalization [PDF]

open access: yes, 2005
How can conflict of laws respond to the challenges from globalization? Some argue that state-based approaches like governmental interest analysis are inadequate, and advocate a return to the approach taken by the German scholar Savigny in the 19th ...
Michaels, Ralf
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

University Textbooks: An Acceptable Conflict of Interest? [PDF]

open access: yes, 2012
Étude de cas / Case studyCette étude de cas examine les conflits d'intérêts qui surviennent lorsque les professeurs d'université utilisent leurs propres manuels comme lectures obligatoires dans leurs cours.This case study examines the conflicts of ...
Williams-Jones, Bryn
core   +1 more source

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