Results 111 to 120 of about 1,521,587 (360)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Leveraging BIM for Proactive Dispute Avoidance in Construction Projects
BuildingsThe construction industry faces persistent challenges from disputes and claims, leading to delays, cost overruns, and strained stakeholder relationships.
Mohamed Tantawy +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The security challenges in conflict prone countries. [PDF]
Conflicts; economic growth; Civil war; post-conflict societies; Violence; Prevention;
Chauvet, Lisa +2 more
core
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The U.S.-Iran Track II Dialogue (20022008): Lessons Learned and Implications for the Rockefeller Brothers Fund's Grantmaking Strategy [PDF]
, 2010 From 2002 through 2008, the Rockefeller Brothers Fund (RBF) supported a Track II dialogue involving influential American and Iranian citizens, co-organized and co-facilitated with the UnitedNations Association of the United States of America (UNA-USA ...
Randa M. Slim
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Tackling Civil Unrest: Policing or Redistribution? [PDF]
There is much evidence to suggest that economic and social factors are major causes of civil unrest. However, governments often resort to the use of police and military to tackle such upheavals, rather than using policies that directly address the causes
Patricia Justino
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Redefining the role of food aid [PDF]
"The principal objective of food aid, besides responding to needs created by conflict, and other disasters, should be to provide an insurance function for those events for which existing insurance mechanisms function poorly" "From TextHunger Prevention ...
Bos, Maria Soledad +2 more
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