Results 131 to 140 of about 1,521,587 (360)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Maintaining Harmonization In Preventing Potential Social-Religious Conflicts In The City of Semarang Through Community Pluralism Education

open access: yesEdukasi Islami: Jurnal Pendidikan Islam
One of the challenges and threats for religious communities today is the existence of religious fundamentalists who are trying to replace the Pancasila ideology. Apart from that, the diverse lives of the people of Semarang City intersect with differences
Sri Suneki   +2 more
doaj   +1 more source

The legal framework for groundwater allocation in Quebec: towards integrated water management [PDF]

open access: yes, 2008
This paper aims at providing a model of the legal framework for groundwater allocation in the province of Quebec (Canada), identifying its potential deficiencies and suggesting possible improvements. In Quebec, groundwater is a res communis. The right to
Tremblay, Hugo
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Is prevention better than cure? An empirical investigation for the case of Avian Influenza [PDF]

open access: yes
The new EU Animal Health Strategy suggests a shift in emphasis away from control towards prevention and surveillance activities for the management of threats to animal health. The optimal combination of these actions will differ among diseases and depend
Huirne, Ruud B.M.   +3 more
core   +1 more source

Proactive Prevention of False-Positive Conflicts in Distributed Ontology Development

open access: gold, 2016
Lavdim Halilaj   +4 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A mini review of conflict management styles in workplaces: the significance of community psychology approach [PDF]

open access: yes, 2014
Conflict management is as a main method in every organization which restricting the negative facets of conflict at workplace and lead to appear positive signs of conflict in organization.
Hamsan, Hanina Halimatusaadiah   +2 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Formation of the culture of the inter-ethnic relations of the school yourth in poly-ethnic regions

open access: yesНаука. Культура. Общество, 2019
The article investigates the process of formation of culture of interethnic communication of school youth in multiethnic regions by the results of large-scale longitudinal studies conducted from 1991 to the present time in Astrakhan, Grozny, Ivanovo ...
Larissa S. Ruban
doaj  

Home - About - Disclaimer - Privacy