Results 161 to 170 of about 1,521,587 (360)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Thirty years of “Peace”: reconsidering the Kantian tradition in Foreign Relations

open access: yesStudia Humanitatis, 2016
The article considers the researcher’s ideas evolving the reconsideration of neo-Kantian approaches to theorizing in foreign relations regarding the effects of globalization upon the international peace in particular.
Mykhaylenko Maksym Valeriyovych
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

A Multidisciplinary Occupational Medicine-Based Intervention Protocol for Conflict Prevention and Crisis Management in High-Stress Professional Environments. [PDF]

open access: yesBrain Sci
Corsi M   +13 more
europepmc   +1 more source

EUÕs Influence in Its Eastern Neighbourhood: The Case of Crisis Management in the Southern Caucasus [PDF]

open access: yes
While the European Neighbourhood Policy has been largely inspired by the successive experiences of enlargement, it has also been designed partly not to replicate exactly enlargement approaches.
Damien Helly
core  

Home - About - Disclaimer - Privacy