Results 91 to 100 of about 149 (149)

Residual Stresses and Micro‐voids Propel Metal Diffusion for Filament‐Based Memristors

Advanced Science, EarlyView.
Introducing non‐reactive nitrogen during silver sputtering enables low‐voltage (<60 mV) switching in memristors via nano‐void formation and residual stresses in the gigapascal range. This promotes sub‐micron filamentation and neuromorphic behaviors, including multi‐peak synaptic responses.
Joel Y.Y. Loh, Jason Yuan, Samuel Moor‐Smith, Adam Glustein, Gloria Vytas, Will Taylor, Andres Lombo, Richard J. Curry, Nazir Pyarali Kherani   +8 more
wiley   +1 more source

The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening

Advanced Science, EarlyView.
A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie, Qingyang Yang, Yanan Zhang, Ke Zheng, Hongya Geng, Yaojiong Wu   +5 more
wiley   +1 more source

Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range

Advanced Science, EarlyView.
ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen, Junyuan Xue, Ziying Wang, Jinyuan Sun, Yinglu Cui, Tong Zhu, Huaiyi Yang, Ming Li, Bian Wu   +8 more
wiley   +1 more source

A Live Cell Imaging‐Compatible Bioreactor for the Interrogation of Cellular Responses to Modulated Flow Conditions

Advanced Science, EarlyView.
An open‐source, low‐cost 3D perfusion system integrating bioprinted scaffolds and live‐imaging overcomes 2D culture limitations. Modeling the cerebrospinal fluid‐filled subarachnoid space, it reveals flow‐dependent focal adhesion kinase activation in meningothelial cells, demonstrating a powerful platform for studying mechanobiology and creating ...
Subashree Srinivasan, Valerie H. Huhle, Claudia C. Bippes, Nina Tanner, Stephan Frank, Hanspeter E. Killer, Corina Kohler, Albert Neutzner   +7 more
wiley   +1 more source

Catalyst‐Free Direct Hydrocarbonation of Terminal Alkynes Toward E‐Alkene Substituted Stabilized Sulfoxonium Ylides

Advanced Science, EarlyView.
The authors introduce a high‐throughput synthesis using amide‐sulfoxonium ylides as new nucleophilic reagents, enabling a catalyst‐ and base‐free hydrocarbonation of terminal alkynes under mild conditions, resulting in various E‐alkene substituted (hetero)amide‐sulfoxonium ylides with excellent regio‐ and stereoselectivity. The late‐stage modifications
Haiting Wu, Yougen Xu, An Lin, Jingyuan Liu, Huanjun Chen, Shimin Xie, Lebin Su   +6 more
wiley   +1 more source

Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models

Advanced Science, EarlyView.
Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye, Sihui Chen, Wei Xiong, Fan Wang, Hon Fai Chan, Haocheng Lai, Xiangyu Guo, Tingting Yang, Shuhao Shen, Hang Chen, Wenxuan Wang, Guei‐Sheung Liu, Yonglong Guo, Jiansu Chen   +13 more
wiley   +1 more source

Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management

Advanced Science, EarlyView.
Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang, Longfei Li, Yiran Hu, Zhou Li, Wei Hua   +4 more
wiley   +1 more source

Accurate and Noninvasive Dysphagia Assessment via a Soft High‐Density sEMG Electrode Array Conformal to the Submental and Infrahyoid Muscles

Advanced Science, EarlyView.
A stretchable, breathable, large‐area high‐density sEMG (HD‐sEMG) electrode array is reported, which enables seamless integration to the complex surface of the submental and infrahyoid muscles to detect high‐fidelity HD‐sEMG signals during swallowing.
Weijie Hong, Lin Mao, Kai Lin, Chongyuan Huang, Yanyan Su, Shun Zhang, Chengjun Wang, Daming Wang, Jizhou Song, Zuobing Chen   +9 more
wiley   +1 more source

The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box

Advanced Science, EarlyView.
High‐resolution imaging of the cochlea is challenged by numerous unique aspects of this organ, where sensorineural cells, crucial for hearing, are too small for conventional modalities like magnetic resonance imaging and computed tomography. This article reviews current imaging techniques, emerging technologies, and innovations aimed at improving ...
Shelley Batts, Nancy Pham, Guillermo Tearney, Konstantina M. Stankovic   +3 more
wiley   +1 more source

Photo‐Rechargeable Organic Supercapacitor via Light‐Activated Electrolytes

Advanced Science, EarlyView.
A photo‐rechargeable organic supercapacitor device is fabricated comprising activated charcoal electrodes and 2‐nitrobenzaldehyde as the electrolyte. The operation principle of the device relies on the photoinduced transformation of 2‐nitrobenzaldehyde into electrochemically active benzoic acid derivatives.
Shubhra Kanti Bhaumik, Sudipta Biswas, Nitzan Shauloff, Ahiud Morag, Raz Jelinek   +4 more
wiley   +1 more source