Results 41 to 50 of about 44,944 (216)

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Black holes and (0,4) SCFTs from type IIB on K3

Journal of High Energy Physics, 2019
We study the central charges and levels of 2d N $$ \mathcal{N} $$ = (0, 4) superconformal field theories that are dual to four- and five-dimensional BPS black holes in compactifications of type IIB string theory on a K3 surface.
Christopher Couzens, Huibert het Lam, Kilian Mayer, Stefan Vandoren   +3 more
doaj   +1 more source

A worldsheet description of instant folded strings

Journal of High Energy Physics, 2023
Time-like linear dilaton backgrounds admit a classical solution that describes a closed folded string that is created at an instant. We refer to such strings as Instant Folded Strings (IFS).
Akikazu Hashimoto, Nissan Itzhaki, Uri Peleg   +2 more
doaj   +1 more source

D-branes in T-fold conformal field theory

, 2008
We investigate boundary dynamics of orbifold conformal field theory involving T-duality twists. Such models typically appear in contexts of non-geometric string compactifications that are called monodrofolds or T-folds in recent literature.
A. Dabholkar, A. Dabholkar, A. Flournoy, A. Lawrence, C.M. Hull, C.M. Hull, D.-E. Diaconescu, E. Hackett-Jones, J. Polchinski, J.A. Harvey, J.M. Maldacena, L. Birke, M. Gualtieri, M. Serone, M.R. Gaberdiel, P. Di Francesco, S. Hellerman, S. Hellerman, S.P. Chowdhury, Shinsuke Kawai, Y. Sugawara, Yuji Sugawara   +21 more
core   +1 more source

Symmetric Subgroups of Gauged Supergravities and AdS String Theory Vertex Operators [PDF]

, 1999
We show how the gauge symmetry representations of the massless particle content of gauged supergravities that arise in the AdS/CFT correspondences can be derived from symmetric subgroups to be carried by string theory vertex operators in these ...
Günaydin M., Kim H., L. DOLAN, M. LANGHAM   +3 more
core   +4 more sources

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

On the gl(1|1) Wess-Zumino-Witten model

Journal of High Energy Physics, 2017
We continue the study of the gl(1|1) Wess-Zumino-Witten model. The Knizhnik-Zamolodchikov equations for the one, two, three and four point functions are analyzed, for vertex operators corresponding to typical and projective representations.
Jan Troost
doaj   +1 more source

From N=2 strings to F&M theory [PDF]

, 1996
Taking the N=2 strings as the starting point, we discuss the equivalent self-dual field theories and analyse their symmetry structure in 2+2 dimensions. Restoring the full `Lorentz' invariance in the target space necessarily leads to an extension of the ...
Berkovits, Bischoff, Bonini, Hull, Ketov, Ketov, Ketov, Ketov, Ketov, Kutasov, Leznov, Lü, Ooguri, Ooguri, Parkes, Plebanski, S.V. Ketov, Siegel, Siegel, Siegel, Townsend, Vafa, Witten, Yang   +23 more
core   +2 more sources

A Self‐Organized Liquid Reaction Container for Cellular Memory

Advanced Science, EarlyView.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee, Enrico Skoruppa, Holger Merlitz, Jens‐Uwe Sommer, Helmut Schiessel   +4 more
wiley   +1 more source

Holographic correlators in AdS3

Journal of High Energy Physics, 2019
We derive the four-point correlators of scalar operators of dimension one in the supergravity limit of the D1D5 CFT holographically dual to string theory on AdS3×S 3×ℳ, with ℳ either T 4 or K3.
Stefano Giusto, Rodolfo Russo, Congkao Wen   +2 more
doaj   +1 more source