Results 71 to 80 of about 115,904,991 (230)

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken   +8 more
wiley   +1 more source

Predicting the Reactivity of Acyclic Silylenes and Germylenes in Hydrogen Activation Using Machine Learning

open access: yesAdvanced Science, EarlyView.
Statistical models for the prediction of the energy profile of H2 activation by silylenes and germylenes were developed. A simple model based on increments of the elements in α‐position enabled robust energy prediction, extrapolation to new structures, and transferability to new tetrylenes and substrates.
Michelle Kleinhaus   +4 more
wiley   +1 more source

Practical Computational Exploration of Chemical Reaction Space: Assessing the Chemical Stability of Active Pharmaceutical Ingredients Under Acidic Conditions

open access: yesAngewandte Chemie, EarlyView.
Metadynamics simulations drive automated reaction exploration of acid‐catalysed drug degradation, generating a network spanning 1720 species and 2471 elementary steps. QM‐based filtering reduces the network to eight candidate pathways for rigorous DFT refinement and microkinetic modelling.
Julius Seumer   +5 more
wiley   +2 more sources

A large-D Weyl invariant string model in anti-de sitter space [PDF]

open access: yes, 2002
In this thesis we present a novel scheme for calculating the bosonic string partition function on certain curved backgrounds related to Anti-de Sitter [AdS] space.
Davies, Ian James
core  

4d/2d Correspondence: Instantons and W-Algebras [PDF]

open access: yes, 2012
In this thesis, we study the 4d/2d correspondence of Alday-Gaiotto-Tachikawa, which relates the class of 4-dimensional N=2 gauge theories (theories of class S) to a 2-dimensional conformal field theory. The 4d gauge theories are obtained by compactifying
Song, Jaewon
core   +1 more source

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

open access: yesAdvanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng   +6 more
wiley   +1 more source

Conformal field theories on random surfaces and the non-critical string [PDF]

open access: yes, 1997
Recently, it has become increasingly clear that boundaries play a significant role in the understanding of the non-perturbative phase of the dynamics of strings.
Neves, Rui Gomes Mendona
core  

Data‐Guided Photocatalysis: Supervised Machine Learning in Water Splitting and CO2 Conversion

open access: yesAdvanced Intelligent Discovery, EarlyView.
This review highlights recent advances in supervised machine learning (ML) for photocatalysis, emphasizing methods to optimize photocatalyst properties and design materials for solar‐driven water splitting and CO2 reduction. Key applications, challenges, and future directions are discussed, offering a practical framework for integrating ML into the ...
Paul Rossener Regonia   +1 more
wiley   +1 more source

Perturbative and non-perturbative studies in low dimensional quantum field theory [PDF]

open access: yes, 2007
A relevant perturbation of a conformal field theory (CFT) on the half-plane, by both a bulk and boundary operator, often leads to a massive theory with a particle description in terms of the bulk S-matrix and boundary reflection factor R.
Lishman, Anna Rebecca
core  

When Biology Meets Medicine: A Perspective on Foundation Models

open access: yesAdvanced Intelligent Discovery, EarlyView.
Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu   +3 more
wiley   +1 more source

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