Results 51 to 60 of about 161,197 (340)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Quantum impurity models from conformal field theory

Journal of High Energy Physics, 2019
The coupling between localized magnetic moments and itinerant electrons presents a plethora of interesting physics. The low-energy physics of some quantum impurity systems can be described using conformal field theory (CFT). In this paper, the connection
Ying-Hai Wu, Hong-Hao Tu
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

On Galilean conformal bootstrap

Journal of High Energy Physics, 2021
In this work, we develop conformal bootstrap for Galilean conformal field theory (GCFT). In a GCFT, the Hilbert space could be decomposed into quasiprimary states and its global descendants.
Bin Chen, Peng-xiang Hao, Reiko Liu, Zhe-fei Yu   +3 more
doaj   +1 more source

Exact Solutions in SFT and Marginal Deformation in BCFT

, 2003
In this note we will study solution of open bosonic string field theory based on action of operators from chiral algebra of boundary conformal field theory on identity element of string field theory star algebra. We will demonstrate that the string field
A. Kling, A. LeClair, A. LeClair, A. Recknagel, A. Sen, A. Sen, A. Sen, A. Sen, A. Sen, B. Zwiebach, D. Gaiotto, D.J. Gross, D.J. Gross, D.M. Belov, G.T. Horowitz, I. Bars, I. Bars, I. Ellwood, I. Kishimoto, I. Kishimoto, I. Kishimoto, I.Y. Arefeva, I.Y. Arefeva, J. Kluson, J. Kluson, J. Kluson, J. Kluson, J. Kluson, J.A. Harvey, Josef Kluson, K. Ohmori, K. Ohmori, K. Ohmori, L. Bonora, L. Bonora, L. Rastelli, L. Rastelli, L. Rastelli, L. Rastelli, L. Rastelli, L. Rastelli, L. Rastelli, M. Schnabl, M.R. Douglas, M.R. Gaberdiel, O. Lechtenfeld, P.-J. De Smet, T. Takahashi, T. Takahashi, T. Takahashi, V. Schomerus, W. Taylor   +51 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Higher dimensional conformal field theories in the Coulomb branch

, 2010
We use the AdS/CFT correspondence to study flows of N=4 SYM to non-conformal theories. The dual geometries can be seen as sourced by a Wigner's semicircle distribution of D3 branes.
Andrianopoli, Arkani-Hamed, Arkani-Hamed, Berkooz, Brandhuber, Buchel, Buchel, Carlisle, Carlos Hoyos, Cvetic, Cvetic, D'Auria, Evans, Fayyazuddin, Freedman, Gubser, Gubser, Kanitscheider, Kraus, Maldacena, Meessen, Paik, Pilch, Pilch, Romans, Romans, Seiberg, Witten   +27 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Stretched horizon from conformal field theory

Journal of High Energy Physics
Recently, it has been observed that the Hartle-Hawking correlators, a signature of smooth horizon, can emerge from certain heavy excited state correlators in the (manifestly non-smooth) BTZ stretched horizon background, in the limit when the stretched ...
Suchetan Das
doaj   +1 more source

Geometry of complexity in conformal field theory

Physical Review Research, 2020
We initiate quantitative studies of complexity in (1+1)-dimensional conformal field theories with a view that they provide the simplest setting to find a gravity dual to complexity.
Mario Flory, Michal P. Heller
doaj   +1 more source